医用三氧治疗稳定期2型糖尿病的临床研究  

Clinical study of medical ozone in the treatment of stable type 2 diabetes mellitus

作　　者：刘济泳 陈水成 谭智进 刘平 LIU Ji-yong;CHEN Shui-cheng;TAN Zhi-jin(Dongguan Shipai Hospital,Dongguan 523330,China)

机构地区：[1]东莞市石排医院,523330

出　　处：《中国实用医药》2021年第15期21-24,共4页China Practical Medicine

摘　　要：目的探讨医用三氧治疗稳定期2型糖尿病的临床效果。方法60例稳定期2型糖尿病患者,随机分为对照组及试验组,各30例。对照组应用常规口服降糖药进行治疗,试验组在对照组的基础上联合应用医用三氧进行治疗。比较两组患者的临床治疗效果,治疗前后的空腹血糖、餐后2 h血糖、糖化血红蛋白、体质量指数(BMI)水平,生活质量评分,治疗前后的炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)]水平。结果试验组患者的总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,试验组患者的空腹血糖(6.05±0.77)mmol/L、餐后2 h血糖(8.49±1.34)mmol/L、糖化血红蛋白(6.13±0.82)%、BMI(21.42±1.67)kg/m~2均低于对照组的(8.14±1.62)mmol/L、(10.17±2.38)mmol/L、(6.95±1.47)%、(24.25±1.74)kg/m~2,差异有统计学意义(P<0.05)。试验组患者的物质生活、精神状态、社会功能、生理机能评分均明显高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组患者的CRP、IL-6、IL-17、TNF-α、IL-1β水平低于对照组,差异有统计学意义(P<0.05)。结论稳定期2型糖尿病治疗中联合医用三氧进行治疗,能更好的控制血糖水平,值得临床大力推广应用。Objective To discuss the clinical effect of medical ozone in the treatment of stable type 2 diabetes mellitus.Methods A total of 60 patients with stable type 2 diabetes mellitus were randomly divided into control group and experimental group,with 30 cases in each group.The control group was treated with conventional oral hypoglycemic drugs,and the experimental group was treated with medical ozone on the basis of the control group.The clinical effect,fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,body mass index(BMI)level before and after treatment,quality of life score,inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)]levels before and after treatment were compared between the two groups.Results The total effective rate of the experimental group was 93.33%,which was higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).After treatment,the fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin and BMI of the experimental group were(6.05±0.77)mmol/L,(8.49±1.34)mmol/L,(6.13±0.82)%and(21.42±1.67)kg/m~2,which were lower than(8.14±1.62)mmol/L,(10.17±2.38)mmol/L,(6.95±1.47)%and(24.25±1.74)kg/m~2 of the control group,and the difference was statistically significant(P<0.05).The material life,mental state,social function,physiological function score of the experimental group were obviously higher than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CRP,IL-6,IL-17,TNF-αand IL-1βof the experimental group were lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion The addition of medical ozone therapy can better control the blood glucose level of patients with stable type 2 diabetes mellitus,and it is worthy of clinical promotion and application.

关 键 词：医用三氧 稳定期2型糖尿病 二甲双胍 阿卡波糖 

分 类 号：R587.1[医药卫生—内分泌]