布洛芬混悬液退热后导致体温不升的危险因素分析  

Analysis of risk factors for hypothermia after ibuprofen suspension treatment in children with fever

作　　者：杨竹 谭薇 左学英 余旭 杨平 张馨月 袁莉 YANG Zhu;TAN Wei;ZUO Xue-ying(Department of Pediatrics,Third Affiliated Hospital of Zunyi Medical University,Zunyi 563002,China)

机构地区：[1]遵义医科大学第三附属医院儿科,563002

出　　处：《中国实用医药》2021年第15期60-63,共4页China Practical Medicine

基　　金：遵义市科技计划课题(2018)176号

摘　　要：目的明确布洛芬混悬液治疗小儿发热后导致体温不升的危险因素。方法回顾性分析299例在本院儿科就诊的发热患儿,采用两项分布家族广义线性效应模型分析各种因素对小儿退热治疗后导致体温不升的危险因素。结果小儿退热治疗后导致体温不升的危险因素是发热期间的最高体温(P<0.05)。当最高体温>39.7℃时出现体温不升的几率越大。另外,最高体温也直接与退热治疗次数和住院天数呈明显的正相关(r=0.55、0.40,P<0.01)。而年龄、性别、体重、白细胞总数、中性粒细胞计数等因素不是布洛芬混悬液治疗小儿发热后导致体温不升的危险因素(P>0.05)。结论使用布洛芬混悬液退热治疗时应密切监测最高体温这一指标,同时应注意控制治疗强度,避免退热过度后出现体温不升。Objective To clarify the risk factors for hypothermia after ibuprofen suspension treatment in children with fever. Methods The clinical data of 299 children with fever in pediatrics department were retrospectively analyzed, and generalized linear model for the binomial family was used to analyze the risk factors of initiating hypothermia after the treatment for fever. Results The risk factor for hypothermia after the treatment for fever was the highest body temperature(P<0.05). When the highest body temperature >39.7 ℃, there was a greater probability of hypothermia. In addition, the maximum body temperature was also positively related to the frequency of fever treatment and hospitalization time(r=0.55, 0.40;P<0.01). Age, gender, weight, total white blood cell count, neutrophil count and other factors were not the risk factors of hypothermia after ibuprofen suspension treatment for children with fever(P>0.05). Conclusion The highest body temperature should be closely monitored when using ibuprofen suspension for antipyretic treatment, and the intensity of treatment should be controlled to avoid hypothermia during antipyretic treatment.

关 键 词：小儿 发热 布洛芬混悬液 低体温 

分 类 号：R969[医药卫生—药理学]