ABO 溶血病新生儿的血清学检测及临床意义研究  

Serological detection of ABO hemolytic disease in newborns and its clinical significance

作　　者：邓妮君 钟婉婷[1] 钟敏仙 DENG Nijun;ZHONG Wan-ting;ZHONG Min-xian(Laboratory Medicine Center,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)

机构地区：[1]佛山市中医院检验医学中心,528000

出　　处：《中国实用医药》2021年第15期69-71,共3页China Practical Medicine

摘　　要：目的评价ABO溶血病新生儿的血清学检测及临床意义。方法88例ABO溶血病新生儿为研究对象,按照ABO溶血三项检查结果分为A组[直接抗球蛋白抗体、游离抗体、抗体释放(+),10例];B组[游离抗体、直接抗球蛋白抗体(+),16例];C组[直接抗球蛋白抗体、抗体释放(+),16例]和D组[抗体释放(+),46例]。四组患儿均给予常规治疗及大剂量免疫球蛋白治疗。检测并比较四组患儿治疗前后血清总胆红素水平。结果治疗前,B组患儿的血清总胆红素为(364.38±52.63)μmol/L,C组患儿的血清总胆红素为(371.25±25.36)μmol/L,D组患儿的血清总胆红素为(382.63±56.68)μmol/L,均高于A组的(319.36±52.36)μmol/L,差异具有统计学意义(P<0.05)。治疗后,四组患儿血清总胆红素水平均低于治疗前,差异具有统计学意义;但四组治疗后血清总胆红素水平对比,差异无统计学意义(P>0.05)。结论为ABO溶血病新生儿进行血清学检测,能够了解其血清总胆红素水平变化情况,对评估新生儿治疗效果有所帮助,所以可推广该方法。Objective To evaluate the serological detection of ABO hemolytic disease in newborns and its clinical significance.Methods A total of 88 newborns with ABO hemolytic disease as study subjects were divided into group A[direct antiglobulin antibody,free antibody,antibody release(+),10 cases],group B[free antibody,direct anti-globulin antibody(+),16 cases],group C[direct anti-globulin antibody,antibody release(+),16 cases]and group D[antibody release(+),46 cases]according to the results of ABO hemolysis.All four groups received conventional treatment and high-dose immunoglobulin therapy.The serum total bilirubin levels of the four groups before and after treatment were compared.Results Before treatment,the serum total bilirubin of group B,group C,group D were(364.38±52.63),(371.25±25.36),(382.63±56.68)μmol/L,which were higher than(319.36±52.36)μmol/L of group A,and the difference was statistically significant(P<0.05).After treatment of serum total bilirubin of the four groups was lower than those before treatment,and the difference was statistically significant(P<0.05).But there was no statistically significant difference in serum total bilirubin of the four groups after treatment(P>0.05).Conclusion Serological detection for ABO hemolytic disease newborns can understand the changes of serum total bilirubin,which is helpful to evaluate the treatment effect of newborns,so this method can be popularized.

关 键 词：ABO溶血病 新生儿血清学检测 血清总胆红素 

分 类 号：R722.18[医药卫生—儿科]