角膜神经性疼痛研究新进展  

New progress in the study of neuropathic corneal pain

作　　者：李植源(综述)[1,2] 邝国平(审校) LI Zhiyuan;KUANG Guoping(Department of Ophthalmology,First People’s Hospital of Chenzhou,Chenzhou Hunan 423000;Dry Eye and Ocular Surface Disease Diagnosis and Treatment Technology Research and Development Center of Chenzhou,Chenzhou Hunan 423000,China)

机构地区：[1]郴州市第一人民医院眼科,湖南郴州423000 [2]郴州市干眼及眼表疾病诊疗技术研发中心,湖南郴州423000

出　　处：《眼科学报》2021年第5期356-363,共8页Eye Science

基　　金：郴州市科技局基金(ZDYF-20200092);郴州市第一人民医院优秀青年基金(N2019-006);南华大学医院管理基金(2019YJGL04)。

摘　　要：角膜神经性疼痛(neuropathic corneal pain,NCP)的患者具有眼部及躯体症状,但临床体征不典型,治疗效果不理想。随着干眼诊治的规范化程度不断提升,NCP的患者日益增多。NCP与全身慢性疼痛综合征相互交织。角膜共聚焦显微镜及活体印迹细胞检测可以发现特征性神经形态及相关蛋白改变。NCP的治疗应基于个体化、多学科联合的原则。本文综述近年来,NCP的病因学、病理生理学、综合治疗等取得新的进展以指导临床及转化医学研究。Patients with neuropathic corneal pain(NCP)have local and physical symptoms,but the clinical signs are atypical,and the treatment is not effect.With the improvement of standardization of diagnosis and treatment of dry eye,the number of patients with NCP has been increasing.The NCP is intertwined with systemic chronic pain syndrome.Corneal confocal microscope and in vivo blot cytology can find the signs of morphology and associated proteins variation.The treatments of NCP should be based on the principle of individualized,multidisciplinary treatment(MDT).This article reviews recent advances in the etiology,pathogenesis,and comprehensive treatment of NCP to guide clinical translational medicine research.

关 键 词：角膜神经性疼痛 全身慢性疼痛综合征 角膜共聚焦显微镜 综合治疗 

分 类 号：R47[医药卫生—护理学]