大肠埃希菌主动外排泵的研究进展  

Research Progress of Active Efflux Pumps in Escherichia Coli

作　　者：闫向龙 石艳春[1] 郑源强[1] 孙瑶 孙颖 栾艳淼 YAN Xianglong;SHI Yanchun;ZHENG Yuanqiang;SUN Yao;SUN Ying;LUAN Yanmiao(Inner Mongolia Key Laboratory of Molecular Biology,Inner Mongolia Medical University,Hohhot 010058,China)

机构地区：[1]内蒙古医科大学内蒙古自治区分子生物学重点实验室,呼和浩特010058

出　　处：《医学综述》2021年第10期1885-1890,共6页Medical Recapitulate

基　　金：国家自然科学基金(81660272)。

摘　　要：大肠埃希菌的主动外排系统是抗生素耐药性的主要机制。外排泵是将抗生素泵出体外的特定蛋白,通常细菌的外排泵系统可以排出不同化学性质的有毒物质,有助于病原菌抵御外界恶劣环境,但也增强了对临床抗菌药的抵抗力,使细菌发生多重耐药。外排泵是细胞输出药物的一种途径,同时也是细胞获得抗微生物和肿瘤化疗耐药性的主要因素。因此,未来应集中于外排泵系统的识别和运输机制、外排泵的结构特点、不同类型外排泵之间的相互作用以及外排泵抑制剂体内外的研究,为探索药物识别和药物输出机制奠定基础。The active efflux system of Escherichia coli is the main mechanism of antibiotic resistance. Usually,the efflux pump system of bacteria can discharge toxic substances with different chemical properties,which not only helps the pathogens to resist the harsh environment,but also enhances the resistance to clinical antibiotics,making the bacteria multiresistant. Efflux pump is a way for cells to export drugs,and it is a major factor for cells to obtain anti-microbial and tumor chemotherapy resistance. Therefore,in the future,the studies should focus on the identification and transport mechanism of efflux pump system,structural characteristics of efflux pumps,the interaction between different types of efflux pumps and the efflux pump inhibitors in vivo and in vitro,so as to provide a basis for exploring the mechanisms of drug identification and drug export.

关 键 词：大肠埃希菌 外排泵 转运蛋白 多重耐药 

分 类 号：R378.2[医药卫生—病原生物学]