脱烯丙基反应研究进展  

Advances in Deallylation

作　　者：王宇 王泾洋 吴啸宇 丁广妮 张兆国[1] 谢小敏[1] Yu Wang;Jingyang Wang;Xiaoyu Wu;Guangni Ding;Zhaoguo Zhang;Xiaomin Xie(School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240;School of Materials Science and Engineering,Nanchang University,Nanchang 330031)

机构地区：[1]上海交通大学化学化工学院,上海200240 [2]南昌大学材料科学与工程学院,南昌330031

出　　处：《有机化学》2021年第4期1337-1358,共22页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21672143);上海交通大学医工交叉(No.YG2017MS26)资助项目。

摘　　要：烯丙基是有机合成中常用的保护基团,具有引入简单,在酸/碱性及还原剂等条件下稳定,在相对温和的条件下选择性地脱保护等特点,在有机合成特别是药物和天然产物的合成研究中具有重要地位.近几十年来,研究者们对各类烯丙基的脱保护方法进行了广泛研究.按碱及还原剂促进、氧化及自由基过程、路易斯酸促进、碘促进、过渡金属催化及电化学方法等分类,对脱烯丙基保护方法的研究进展进行了综述.Allyl groups,as a kind of universal protective groups in organic synthesis,are easily introduced,and stable under acidic,basic and reductive conditions.Moreover,the deallylation may occur efficiently and selectively under mild conditions.Therefore,functional group protection with allyl moiety plays a significant role in organic synthesis,especially in the synthesis of natural products and pharmaceutical industry.In recent decades,various methods of deallylation have been developed.Herein,the comprehensive development on the deallylation reaction with base and reductant,oxidation and free radical,Lewis-acid,iodine,transition metals,and electrochemical methods is reviewed.

关 键 词：脱烯丙基反应 碱促进脱烯丙基化 过渡金属催化脱烯丙基化 氧化脱烯丙基化 自由基历程脱烯丙基化 路易斯酸催化脱烯丙基化 电化学脱烯丙基化 

分 类 号：O621.25[理学—有机化学]