深海真菌Diaporthe phaseolorum FS459的聚酮类化合物研究  

Polyketides from the Deep-Sea-Derived Fungus Diaporthe phaseolorum FS459

作　　者：胡彩云 李赛妮 陈玉婵[1] 高晓霞 刘昭明 章卫民[1] Caiyun Hu;Saini Li;Yuchan Chen;Xiaoxia Gao;Zhaoming Liu;Weimin Zhang(State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,Guangdong Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070;College of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006)

机构地区：[1]广东省微生物研究所,广东省科学院,华南应用微生物国家重点实验室,广东省菌种保藏与应用重点实验室,广东省微生物应用新技术公共实验室,广州510070 [2]广东药科大学药学院,广州510070

出　　处：《有机化学》2021年第4期1591-1598,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.41906106,31272087);广东省海洋经济发展专项基金(No.GDNRC[2020]042);广东省科学院建设国内一流研究机构行动专项(No.2019GDASYL-0103007);广东省自然科学基金(No.2016A030312014)资助项目。

摘　　要：从深海真菌Diaporthe phaseolorum FS459中分离出10个聚酮化合物,包括3个新的色酮衍生物(1、2和5),一对新的差向异构体混合物(3和4),1个新的Azaphilone类似物(6)及4个已知的化合物(7-10).它们的结构是基于综合波谱分析进行确定,同时其绝对构型通过对比实测电子圆二色谱(ECD)曲线与量子化学计算得出的理论值来确定.化合物1-4具有罕见的2',3'-二甲基二氧戊环结构单元.此外,本研究还评估了化合物1-10的体外细胞毒性、抗菌活性及NO产生的抑制效果.Ten polyketides,including three new chromone derivatives(1,2 and 5),a pair of new epimer mixtures(3 and 4),a new azaphilone analogue(6)and four known compounds(7-10)were isolated from the deep-sea-derived fungus Diaporthe phaseolorumFS459.Their structures were elucidated by extensive spectroscopic analysis,while the absolute configurations were established by comparison of experimental and quantum chemical calculated electronic circular dichroism(ECD)spectra.Compounds 1-4 possessed a rare 2’,3’-dimethyl-dioxolane moiety.Thein vitro cytotoxicity,antibacterial activities and NO production inhibitory effects of compounds 1-10 were evaluated.

关 键 词：聚酮 深海真菌 Diaporthe phaseolorum 细胞毒 

分 类 号：TQ460.1[化学工程—制药化工]