降钙素原、前白蛋白、中性粒细胞百分比联合检测在儿童细菌性肠炎诊断中的应用  

Combination of procalcitonin,prealbumin and percentage of neutrophils for the diagnosis of bacterial infectious enteritis in children

作　　者：冯实[1] 王彦[2] 赵海歌 Feng Shi;Wang Yan;Zhao Haige(Clinical laboratory,Hebei Rongjun Hospital,Hebei Baoding 071000,China;Clinical laboratory,Affiliated Hospital of Hebei University,Hebei Baoding 071000,China)

机构地区：[1]河北省荣军医院检验科,河北保定071000 [2]河北大学附属医院检验科,河北保定071000

出　　处：《新发传染病电子杂志》2021年第2期109-112,共4页Electronic Journal of Emerging Infectious Diseases

基　　金：河北省重点科技计划(18277762D)。

摘　　要：目的探讨降钙素原(PCT)、前白蛋白(PA)、中性粒细胞百分比(NP)联合检测对儿童细菌性肠炎的诊断价值,以期为该类患者的临床诊断、治疗提供理论依据。方法回顾性分析2019年9月至2020年5月河北大学附属医院确诊的感染性肠炎患儿107例,分为细菌性肠炎组(n=76)及病毒性肠炎组(n=31),另选取我院门诊行健康体检儿童50例纳入健康组;比较三组患儿PCT、PA及NP水平,并分析以上指标与细菌性肠炎的相关性及各指标单项及联合检测对细菌性肠炎的诊断效能。结果细菌性肠炎组、病毒性肠炎组PCT水平高于健康组(P<0.05),细菌性肠炎组PCT水平高于病毒性肠炎组(P<0.05);细菌性肠炎组、病毒性肠炎组PA低于健康组(P<0.05),细菌性肠炎组PA低于病毒性肠炎组(P<0.05);细菌性肠炎组、健康组NP高于病毒性肠炎组(P<0.05),细菌性肠炎组NP高于健康组(P<0.05)。PCT、PA及NP水平与儿童细菌性肠炎呈明显相关(P<0.05)。3项指标联合检测诊断儿童细菌性肠炎的ROC曲线的曲线下面积(AUC)为0.921,明显大于PCT、PA、NP(均P<0.05)。3项指标联合检测诊断儿童细菌性肠炎的敏感度和特异度均高于PCT、PA、NP。以约登指数最大为原则取值,获得PCT、PA、NP最佳诊断截断值分别为1.21ng/ml、168.07μg/ml、72.98%,联合检测为0.563。结论PCT、PA、NP与儿童细菌性肠炎密切相关,3项指标联合检测可进一步提高诊断效能。Objective To investigate the diagnostic value of procalcitonin(PCT),proalbumin(PA)combined with percentage of neutrophils(NP)in children with bacterial infectious enteritis,in order to provide theoretical basis for clinical diagnosis and treatment of such patients.Methods Retrospective analysis of 107 children with infectious enteritis diagnosed in Affiliated Hospital of Hebei University from September 2019 to May 2020,which were divided into bacterial enteritis group(n=76)and viral enteritis group(n=31).Another 50 children who underwent physical examination in outpatient department of our hospital were included in the healthy group.PCT,PA and NP levels of children in the three groups were compared,and the correlation between the above indicators and bacterial infectious enteritis was analyzed,as well as the diagnostic efficacy of each indicator and combined test for bacterial enteritis was explored.Results The PCT level of the bacterial enteritis group and viral enteritis group was higher than that of healthy group(P<0.05),and the PCT level of the bacterial enteritis group was higher than that of viral enteritis group(P<0.05).The PA level of the bacterial enteritis group and viral enteritis group was lower than that of healthy group(P<0.05),and the PA level of bacterial enteritis group was lower than that of viral enteritis group(P<0.05).The NP of bacterial enteritis group and healthy enteritis group was higher than that of viral enteritis group(P<0.05),The NP of bacterial enteritis group was higher than that in healthy enteritis group(P<0.05).The PCT,PA and NP levels were significantly correlated with bacterial infectious enteritis in children(P<0.05).The AUC for the combined detection of 3 indexes was 0.921,significantly higher than the PCT,PA and NP(P<0.05).The sensitivity and specificity of he combined detection of 3 indexes were higher than the PCT,PA and NP.Taking the maximum Youden index as the principle,the optimal diagnostic cutoff values of PCT,PA and NP were 1.21 ng/ml,168.07μg/ml and 72.98%respectiv

关 键 词：细菌性肠炎 儿童 降钙素原 前白蛋白 中性粒细胞百分比 

分 类 号：R725.7[医药卫生—儿科]