炎症因子及其相关信号通路在内耳疾病中的研究进展  

Research Progress Regarding Inflammatory Factors and Their Signaling Pathways in Inner Ear Diseases

作　　者：刘宇超 尹时华[1] LIU Yuchao;YIN Shihua(Department of Otolaryngology&Head and Neck Surgery,Second Affiliated Hospital of Guangxi Medical University,Nanning 530000,China)

机构地区：[1]广西医科大学第二附属医院耳鼻咽喉头颈外科,南宁530000

出　　处：《中华耳科学杂志》2021年第3期506-510,共5页Chinese Journal of Otology

基　　金：广西自然科学基金(NO.2015GXNSFAA414004,NO.2016GXNSFAA380150)。

摘　　要：内耳疾病,如感音神经性耳聋和耳鸣,是耳科的常见病和难治性疾病,并且会严重影响患者的生活质量。它们的发病机制目前尚未清晰。相关研究发现,炎症因子在一定程度上影响着众多内耳疾病的发病。本文主要综述了肿瘤坏死因子α(TNF-α)、白介素1(IL-1)、白介素6(IL-6)及其相关信号通路在内耳疾病中的研究现状。Inner ear diseases,such as sensorineural deafness and tinnitus,are often difficult to treat and can seriously affect the quality of life of patients.Their pathogenesis is not always clear.Studies have found that inflammatory factors to a certain extent affect pathogenesis of many inner ear diseases.In this review,the role of tumor necrosis factor cytokines(TNF-α),interleukin 1(IL-1),interleukin 6(IL-6)and their signaling pathways in inner ear diseases is summarized.

关 键 词：内耳疾病 信号通路 TNF-Α IL-1 IL-6 

分 类 号：R764[医药卫生—耳鼻咽喉科]