感觉神经性嗅觉功能障碍的治疗研究进展  

Research progress in the treatment of sensorineural olfactory dysfunction

作　　者：陈银 俞晨杰[1,2,3] 钱晓云 高下[1,2,3] CHEN Yin;YU Chenjie;QIAN Xiaoyun

机构地区：[1]南京医科大学鼓楼临床医学院耳鼻咽喉头颈外科,南京210008 [2]南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科,江苏省医学重点学科 [3]南京鼓楼医院耳鼻咽喉研究所

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第4期365-370,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：江苏省科教强卫工程江苏省医学重点学科资助(No:ZDXKB2016015);十三五南京市青年卫生人才培养工程(No:QRX17051)。

摘　　要：嗅觉是中枢神经系统对气味激活嗅觉受体(olfactory receptor)的感觉,溴素首先到达嗅上皮(olfactory epithelium),与嗅感觉神经元(olfactory receptor neurons, ORNs)的嗅觉受体结合产生神经冲动,经嗅神经纤维到达嗅球(olfactory bulb),随后通过嗅球中的轴突投射到大脑皮层,并终止于额叶和内侧颞叶的几个区域,包括梨状皮质、杏仁核和前杏仁核以及前额叶内侧皮质[1]。Sensorineural olfactory dysfunction refers to the reduction or distortion of sensory intensity due to insufficient reception or processing of stimulation by olfactory receptors, olfactory sensory neurons or central nervous system. As olfactory dysfunction can affect patients’ physical and mental health and even safety of life and the etiology of sensorineural olfactory dysfunction is complicated, it has great clinical significance for understanding the development of olfactory dysfunction’s treatment. This article summarizes the current promising treatment for sensorineural olfactory dysfunction, including drug therapy, cell therapy, gene therapy and olfactory training.

关 键 词：嗅觉障碍 药物疗法 细胞疗法 基因疗法 

分 类 号：R765.6[医药卫生—耳鼻咽喉科]