微小RNA与室性心律失常的研究进展  

The research progress of microRNAs and ventricular arrhythmias

作　　者：王超 钟国强[1] WANG Chao;ZHONG Guoqiang(Department of Cardiology,the First Affiliated Hosptial of Guangxi Medical University,Nanning,530021,China)

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《临床心血管病杂志》2021年第4期365-369,共5页Journal of Clinical Cardiology

基　　金：国家自然科学基金(No:82060068);广西自然科学基金(No:2017JJA10743)。

摘　　要：室性心律失常常发生于心肌损伤、急慢性心肌缺血或非缺血性心肌疾病导致的器质性心脏病和心脏离子通道病等,也可在正常心脏发生。微小RNA是具有约22个核苷酸的小内源性非编码RNA。近年来,微小RNA在心血管疾病中的调控作用成为研究热点。本文主要综述微小RNA与室性心律失常的研究进展,尤其是微小RNA可能是室性心律失常诊断的潜在生物标志物及治疗靶点。Ventricular arrhythmia often occurs due to myocardial injury,organic heart disease caused by acute or chronic myocardial ischemia or non-ischemic myocardial diseases,and cardiac ion channel disease.It can also occur in the normal heart.MicroRNA is a small endogenous non-coding RNA with approximately 22 nucleotides.In recent years,the regulatory role of microRNAs in cardiovascular diseases has become a research hotspot.This article mainly reviews the research progress of microRNAs and ventricular arrhythmias,especially microRNAs may be a potential biomarker and therapeutic target of ventricular arrhythmias.

关 键 词：室性心律失常 微小RNA 治疗靶点 

分 类 号：R541.7[医药卫生—心血管疾病]