肠道微生物及其代谢产物与宿主脂质代谢研究进展  

Recent advances in the interaction between gut microbiota/metabolites and host lipid metabolism

作　　者：龚赛明 马杰[1] 李凤娜[2] 李铁军[2] 刘刚 谭碧娥 黄兴国[1] 尹杰[1] 印遇龙[1,2] GONG SaiMing;MA Jie;LI FengNa;LI TieJun;LIU Gang;TAN BiE;HUANG XingGuo;YIN Jie;YIN YuLong(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,China;College of Bioscience and Biotechnology,Hunan Agricultural University,Changsha 410128,China)

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128 [2]中国科学院亚热带农业生态研究所,长沙410125 [3]湖南农业大学生物科学技术学院,长沙410128

出　　处：《中国科学：生命科学》2021年第4期375-383,共9页Scientia Sinica(Vitae)

基　　金：中国科协青年人才托举工程(批准号:2019-2021QNRC001);国家自然科学基金(批准号:U20A2055);湖南省优秀青年基金(批准号:2020JJ3023)资助。

摘　　要：近年来,肠道微生物与宿主脂质代谢研究受到国内外的广泛关注.首先,肠道微生物多样性和组成在脂肪代谢紊乱动物模型、肥胖患者中均发生显著改变,而利用粪菌移植、益生菌以及营养干预重塑肠道菌群结构可以调控宿主脂质代谢.本文重点介绍了肠道微生物与宿主脂代谢的联系,并从短链脂肪酸、胆汁酸、氨基酸、内毒素和微生物节律等方面探讨了肠道微生物调控宿主脂代谢的潜在机制,以期为脂质代谢引起的疾病提供干预靶点.In recent years, the study of gut microbiota and host lipid metabolism has received widespread attention. Firstly, the diversity and compositions of gut microbiota are significantly altered in animal models of lipodystrophia or human clinical trials, and the host lipid metabolism can also be regulated by reshaping the gut microbiota compositions using fecal bacteria transplantation, probiotics, and nutritional interventions. In this paper, we discuss the link between gut microbes and host metabolism, and summarize the studies focusing on the mechanisms of lipid metabolism regulated by gut microbes: short-chain fatty acids, bile acids, amino acids, endotoxin and microbial rhythms, in order to provide targets for nutritional intervention in lipid dysmetabolism-caused diseases.

关 键 词：肠道微生物 脂质代谢 肥胖 

分 类 号：R333.3[医药卫生—人体生理学]