老树新花——芳香烃受体在环境化学物毒性效应中的作用  

An old tree with fresh blooms:role of aryl hydrocarbon receptors in the toxicity of environmental chemicals

作　　者：陈涛[1] CHEN Tao(School of Public Health,Medical College of Soochow University,Suzhou,Jiangsu 215123,China)

机构地区：[1]苏州大学医学部公共卫生学院,江苏苏州215123

出　　处：《环境与职业医学》2021年第4期329-331,共3页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金面上项目(81972999)。

摘　　要：芳香烃受体(AhR)是重要的环境化学物感受器,虽长期受到关注,但多数研究集中于其受外源化学物激活后对代谢酶的调控作用。近年来发现AhR在生理状态下可以被内源性配体激活,并与多条信号通路有交互作用,介导多种生命活动。环境化学物也可能通过干扰AhR正常功能而导致疾病发生。本文对AhR在环境化学物毒性效应中作用的研究现况进行介绍。Aryl hydrocarbon receptor(AhR)as an important environmental chemical sensor has received long-term attention,but most research focuses on the regulation of metabolizing enzymes in response to exogenous chemicals.Recently,AhR has been found to be activated by endogenous ligands under physiological conditions,and interact with a large number of signal pathways to mediate a variety of life activities.Environmental chemicals may also cause diseases by interfering with the physiological function of AhR.The purpose of this paper is to provide an overview of AhR-mediated environmental chemical toxicity.

关 键 词：芳香烃受体 环境化学物 信号通路 毒作用 

分 类 号：R12[医药卫生—环境卫生学]