芳香烃受体介导环境化学物毒作用的研究进展  

Advances on toxic effects of environmental chemicals mediated by aryl hydrocarbon receptors

作　　者：陈金 黄玉洁 陶怡舟 姜岩[2] 陈涛[1] CHEN Jin;HUANG Yujie;TAO Yizhou;JIANG Yan;CHEN Tao(School of Public Health,Medical College of Soochow University,Suzhou,Jiangsu 215123,China;School of Biology and Basic Medical Sciences,Medical College of Soochow University,Suzhou,Jiangsu 215123,China)

机构地区：[1]苏州大学医学部公共卫生学院,江苏苏州215123 [2]苏州大学医学部基础医学与生物科学学院,江苏苏州215123

出　　处：《环境与职业医学》2021年第4期356-360,388,共6页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金面上项目(81972999)。

摘　　要：芳香烃受体(AhR)是重要的环境化学物感受器。以往认为AhR可被二噁英等大分子化学物激活,作为转录因子调控包括多种代谢酶的靶基因表达。然而,近年来研究表明AhR可由不同类型的配体激活,调控多种靶基因表达。环境化学物可能通过AhR作用于多种信号通路,打破细胞稳态,导致病变。本文主要对AhR介导的环境化学物心脏发育毒性、神经毒性、致癌作用及免疫毒性及作用机制的最新进展进行综述。对AhR激活机制及其毒作用机制的深入了解将有助于预防和治疗环境化学物所导致的人类健康危害。Aryl hydrocarbon receptor(AhR)is an important environmental chemical sensor.Traditionally,AhR is defined as a transcription factor activated by macromolecular chemicals such as dioxins,and regulating the expression of a variety of genes including metabolizing enzymes.However,recent studies show that AhR can be activated by different types of ligands and regulate a wide range of target genes.Environmental chemicals may affect multiple signaling pathways via AhR,and disrupt cellular homeostasis,resulting in pathologic changes.In this paper,we reviewed the recent progress and mechanisms of AhR-mediated cardiac developmental toxicity,neurotoxicity,carcinogenesis,immunotoxicity,and other toxicities of environmental chemicals.A comprehensive understanding of AhR activation and its toxicity mechanisms may conduce to the prevention and treatment of human diseases caused by environmental chemicals.

关 键 词：芳香烃受体 环境化学物 转录因子 细胞稳态 

分 类 号：R12[医药卫生—环境卫生学]