母孕期和婴儿早期钙剂补充对 婴儿骨密度、骨代谢及肠道菌群的影响  

Effects of calcium supplementation during pregnancy and early infancy on infant bone mineral density,bone metabolism and intestinal flora.

作　　者：宓颖颖 邓朝晖[1] 刘利敏 MI Ying-ying;DENG Zhao-hui;LIU Li-min(Department of Gastroenterology,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China;Department of Gastroenterology,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China.)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心消化内科,上海200127 [2]上海交通大学医学院附属上海儿童医学中心消化科,上海200127

出　　处：《临床和实验医学杂志》2021年第9期979-983,共5页Journal of Clinical and Experimental Medicine

基　　金：上海市卫生和计划生育委员会基金(编号:20144Y0165)。

摘　　要：目的探索母孕期和婴儿早期钙剂补充对婴儿骨密度、骨代谢及肠道菌群的影响。方法回顾性选取2017年7月至2018年7月上海交通大学医学院附属上海儿童医学中心收治的100例正常产检孕妇,根据干预方式分为2组,每组各50例。对照组采用常规孕期保健宣教,新生儿娩出后,进行人工混合喂养或母乳喂养;观察组注重孕期及新生儿的早期钙剂补充干预。比较2组孕妇骨密度、血钙浓度;比较2组新生儿骨代谢、骨密度、体重、肠道菌群等情况。结果分娩后,观察组产妇骨密度优于对照组,差异有统计学意义(P<0.05);2组孕妇血钙浓度比较,差异无统计学意义(P>0.05)。2组新生儿身高比较,差异无统计学意义(P>0.05),观察组新生儿出生后骨密度、体重均显著高于对照组,差异均有统计学意义(P<0.05)。观察组新生儿出生后1、7、14 d骨碱性磷酸酶、甲状旁腺素水平均显著低于对照组,25-羟基维生素D3水平显著高于对照组,差异均有统计学意义(P<0.05)。2组新生儿拟杆菌门、变形菌门、放线菌门、厚壁菌门比较差异均无统计学意义(P>0.05),而观察组新生儿乳酸菌属构成比低于对照组,双歧杆菌属构成比高于对照组,差异均有统计学意义(P<0.05)。结论母孕期和婴儿早期钙剂补充能够助于新生儿骨骼发育,促进肠道乳酸菌属生长,改善骨代谢水平,提高骨密度。Objective To explore the effects of calcium supplementation during pregnancy and early infancy on infant bone mineral density,bone metabolism and intestinal flora.Methods A total of 100 pregnant women with normal obstetrics who were admitted in Shanghai Children's Medical Center,School of Medicine,Shanghai Jiaotong University between July 2017 and July 2018 were retrospectively selected.They were divided into 2 groups according to the intervention method,with 50 cases in each group.The control group used conventional health education during pregnancy.After the newborns were delivered,artificial mixed feeding or breastfeeding;observation group focused on early calcium supplement intervention during pregnancy and newborns.The bone mineral density and blood calcium concentration of the two groups of pregnant women were compared,and the bone metabolism,bone density,and weight of the two groups after the newborn,intestinal flora,etc.were compared.Results After delivery,the maternal bone density of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05);while there was no statistically significant difference between the two groups of pregnant women's blood calcium concentration(P>0.05).There was no statistically significant difference in the height of newborns between the two groups(P>0.05),while the bone density and weight of the newborns in the observation group were significantly higher than those in the control group after birth,and the differences were statistically significant(P<0.05).The levels of bone alkaline phosphatase and parathyroid hormone in the observation group were significantly lower than those in the control group at 1,7,and 14 days after birth,and the levels of 25-hydroxyvitamin D3 were significantly higher than those in the control group,the differences were statistically significant(P<0.05).There were no significant difference between the two groups of neonatal Bacteroides,Proteobacteria,Actinobacteria,and Firmicutes(P>0.05),the com

关 键 词：母孕期 婴儿 钙剂 骨密度 骨代谢 肠道菌群 

分 类 号：R473.72[医药卫生—护理学]