右美托咪定复合氟比洛芬酯对重度烧伤全麻患者拔管期心血管反应及苏醒期躁动的影响  

Influence of Dexmedetomidine Combined with Flurbiprofen Axetil on Cardiovascular Response during Extubation and Restlessness during Wake-up Period in Patients with Severe Burn under General Anesthesia

作　　者：张源志 ZHANG Yuanzhi(Burn Operating Room,Xinxiang Second People's Hospital,Xinxiang 453002,China)

机构地区：[1]新乡市第二人民医院烧伤手术室,河南新乡453002

出　　处：《临床医学工程》2021年第5期625-626,共2页Clinical Medicine & Engineering

摘　　要：目的探讨右美托咪定复合氟比洛芬酯对重度烧伤全麻患者拔管期心血管反应及苏醒期躁动的影响。方法选取2018年3月至2019年3月我院收治的重度烧伤患者68例,随机分为对照组和观察组各34例。观察组静脉注射右美托咪定复合氟比洛芬酯,对照组静脉注射等容量生理盐水。比较两组患者拔管前(T0)、拔管时(T1)、拔管后5 min(T2)的心率(HR)、平均动脉压(MAP)以及拔管时间、苏醒时间、苏醒期躁动情况。结果观察组T0、T1、T2时的HR、MAP均低于对照组(P<0.05)。两组的拔管时间、苏醒时间比较差异无统计学意义(P>0.05)。观察组苏醒期躁动发生率为8.82%,低于对照组的29.41%(P<0.05)。结论右美托咪定复合氟比洛芬酯可有效减少重度烧伤全麻患者拔管期心血管反应及苏醒期躁动,且不影响拔管时间及苏醒时间。Objective To explore the influence of dexmedetomidine combined with flurbiprofen axetil on cardiovascular response during extubation and restlessness during wake-up period in patients with severe burn under general anesthesia.Methods 68 patients with severe burn admitted to our hospital from March 2018 to March 2019 were selected and randomly divided into observation group and control group,with 34 cases in each group.The observation group was given intravenous injection of dexmedetomidine combined with flurbiprofen axetil,while the control group was given intravenous injection of equal-volume normal saline.The heart rates(HR)and mean arterial pressure(MAP)before extubation(T0),at extubation(T1)and 5 minutes after extubation(T2),and the extubation time,wake-up time and restlessness during recovery were compared between the two groups.Results The HR and MAP at T0,T1 and T2 of the observation group were lower than those of the control group(P<0.05).No statistical difference was found in the extubation time and wake-up time between the two groups(P>0.05).The incidence of restlessness during wake-up period in the observation group was 8.82%,lower than 29.41%in the control group(P<0.05).Conclusions Dexmedetomidine combined with flurbiprofen axetil can effectively reduce the cardiovascular response during extubation and the restlessness during wake-up period in patients with severe burn under general anesthesia,without affecting the extubation time and wake-up time.

关 键 词：右美托咪定 氟比洛芬酯 重度烧伤 全麻 

分 类 号：R614[医药卫生—麻醉学]