不同剂量索利那新分别联合醒脾养儿颗粒治疗小儿原发性夜间遗尿症  

Clinical Study on Different Doses of Solinaxin Combined with Xingpi Yanger Granule in the Treatment of Primary Nocturnal Enuresis in Children

作　　者：毛婷婷 李桂芬 曹华平 吴煌[2] MAO Ting-ting;LI Gui-fen;CAO Hua-ping;WU Huang(Dept.of Pediatric Internal Medicine,The Third People’s Hospital of Yichang City,Yichang Hubei 443000;Dept.of Bone Surgery,The Second People’s Hospital of Three Gorges University(Yichang Municipal Second People’s Hospital),Yichang Hubei 443000,China)

机构地区：[1]宜昌市第三人民医院儿内科,湖北宜昌443000 [2]三峡大学第二人民医院/宜昌市第二人民医院骨外科,湖北宜昌443000

出　　处：《昆明医科大学学报》2021年第5期126-130,共5页Journal of Kunming Medical University

基　　金：湖北省自然科学基金资助项目(2017CFB567)。

摘　　要：目的探讨不同剂量索利那新联合醒脾养儿颗粒对小儿原发性夜间遗尿症(PNE)的疗效。方法选取2018年3月至2020年1月湖北省宜昌市第三人民医院儿内科收治的120例PNE患儿为研究对象,采用随机数字表法分为A组(40例,低剂量索利那新联合醒脾养儿颗粒)、B组(40例,中剂量索利那新联合醒脾养儿颗粒)、C组(40例,高剂量索利那新联合醒脾养儿颗粒)。对比3组临床疗效,对比3组患儿治疗前后膀胱容量、膀胱容量壁厚指数(BVWI),对比3组患儿复发情况,对比3组患儿治疗期间不良反应发生情况。结果3组总有效率对比差异无统计学意义(P>0.05);3组患儿治疗前膀胱容量、BVWI差异均无统计学意义(P>0.05),3组治疗后膀胱容量较治疗前均明显提高(P<0.05),治疗后BVWI较治疗前均明显降低(P<0.05),3组治疗后膀胱容量、BVWI差异均无统计学意义(P>0.05);3组患儿治疗3个月后、治疗6个月后复发率差异均无统计学意义(P>0.05);C组不良反应发生率高于A组、B组(P<0.05),B组不良反应发生率高于A组(P>0.05)。结论低、中、高剂量索利那新联合醒脾养儿颗粒治疗小儿PNE疗效相近,均可改善患儿膀胱功能,且对其复发率影响不大,但高剂量索利那新可明显增加不良反应的发生,从安全性考虑建议临床选取低剂量索利那新。Objective To investigate the effect of different doses of Solina xin combined with Xingpi Yanger granule on primary nocturnal enuresis(PNE)in children.Methods From March 2018 to January 2020,120 PNE children admitted to Pediatric Internal Medical Department in The Third People’s Hospital of Hubei province Yichang city were selected as the study subjects.The patients were divided into Group A(40 cases,low-dose Solina Xinlianxingpi Yanger granule),group B(40 cases,medium-dose Solina Xinlianxingpi Yanger granule),and group C(40 cases,high-dose Solina Xinlianxingpi Yanger granule)by using the random number table method.The clinical efficacy of the three groups was compared.Bladder volume and bladder volume wall thickness index(BVWI)before and after the treatment were compared among the 3 groups.The relapses of the 3 groups were compared.The occurrence of adverse reactions during the treatment was compared among the 3 groups.Results There was no significant difference in the total effective rate among the 3 groups(P>0.05).There were no statistically significant differences in bladder volume and BVWI among the 3 groups before the treatment(P>0.05).Bladder volume was significantly increased after the treatment compared with that before the treatment in the 3 groups(P<0.05),and BVWI was significantly decreased after the treatment compared with that before the treatment(P<0.05).There were no statistically significant differences in bladder volume and BVWI among the 3 groups after the treatment(P>0.05).There was no statistically significant difference in the recurrence rate after 3 months and 6 months of treatment among the 3 groups(P>0.05).The incidence of adverse reactions in group C was higher than that in group A and group B(P<0.05),and the incidence of adverse reactions in group B was higher than that in group A(P>0.05).Conclusion Low,medium and high doses of Solinaxin combined with Xingpi Yanger Granule have similar effects on the treatment of PNE in children,both of which can improve the bladder function of childr

关 键 词：索利那新 醒脾养儿颗粒 小儿 原发性夜间遗尿症 效果 

分 类 号：R726.9[医药卫生—儿科]