四氢叶酸还原酶基因多态性与冠心病严重程度的相关性  

The Association of Methylenetetrahydrofolate Reductase Gene Polymorphism with Coronary Heart Disease

作　　者：李柳[1] 张晓婵[1] 茹琪 王硕 戚国庆[1] 赵红亮[1] LI Liu;ZHANG Xiao-chan;RU Qi;WANG Shuo;QI Quo-qing;ZHAO Hong-liang(Dept.of Cardiology,Hebei Medical University First Hospital,Shijiazhuang Hebei 050031;Dept.of Cardiology,Shijiazhuang First Hospital,Shijiazhuang Hebei 050011,China)

机构地区：[1]河北医科大学第一医院心内3科,河北石家庄050031 [2]石家庄市第一医院心内4科,河北石家庄050011

出　　处：《昆明医科大学学报》2021年第5期138-142,共5页Journal of Kunming Medical University

基　　金：河北省卫生和计划生育委员会科研基金资助项目(20190471)。

摘　　要：目的评价四氢叶酸还原酶基因(MTHFR)多态性与冠心病严重程度的相关性。方法研究对象为需行冠脉造影术及必要时支架植入术患者400名,行叶酸代谢677基因检测,按MTHFR C677T多态性分为野生型C/C、纯合突变型C/T、杂合突变型T/T 3组,并行冠脉Gensini评分,随访所有行PCI患者术后180 d内发生MACE事件(包括心脏死亡、心肌梗死、心力衰竭、心脏原因再次入院、靶血管再次血运重建)的情况。结果(1)MTHFR C677T T/T基因型患者冠脉Gensini评分显著高于C/T、C/C基因型患者(P<0.05);(2)MTHFR C677T T/T基因型患者术后180 d内发生的MACE事件显著高于C/T、C/C基因型患者(P<0.05)。结论(1)MTHFR多态性与冠脉病变严重程度显著相关;(2)MTHFR多态性与冠心病患者术后180 d内发生的MACE事件显著相关。Objective To analyze the relationship between methylenetetrahydrofolate reductase(MTHFR)gene polymorphism and severity of coronary heart disease.Methods A total of 400 patients who were to undergo coronary angiography and stent implantation when necessary were tested with folate metabolism 677 gene.And according to MTHFR C677T polymorphism,these patients were divided into three groups:C/C,C/T,T/T and Gensini score of coronary artery was used to evaluate the mace events(including cardiac death,myocardial infarction,heart failure,readmission for cardiac reasons and target vessel revascularization)within 180 days after PCI.Results(1)Patients with MTHFR C677T T/T genotype had significantly higher Gensini scores than those with C/T and C/C genotypes(P<0.05).(2)Patients with MTHFR C677T T/T genotype had significantly higher mace events than those with C/T and C/C genotypes after 180 days of PCI(P<0.05).Conclusion(1)There is a significant correlation between MTHFR gene polymorphism and severity of coronary heart disease;(2)There is a significant correlation between MTHFR gene polymorphism and the mace events after 180 days of PCI.

关 键 词：四氢叶酸还原酶 冠脉Gensini评分 PCI MACE 

分 类 号：R541.4[医药卫生—心血管疾病]