慢性肺心病急性加重期患者动脉血气、NT-proBNP与hs-CRP水平变化及临床意义  

Changes and Clinical Significance of Arterial Blood Gas,NT-proBNP and hs-CRP Levels in Patients with Acute Exacerbation of Chronic Cor Pulmonale

作　　者：段勇弟 石中方 DUAN Yongdi;SHI Zhongfang(Jianli Hospital of Traditional Chinese Medicine,Jianli 433300,China;不详)

机构地区：[1]监利市中医医院,湖北监利433300

出　　处：《中外医学研究》2021年第14期30-32,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨检测慢性肺心病急性加重期患者动脉血气、血浆N末端B型利钠肽原(NT-proBNP)和超敏CRP(hs-CRP)对评估患者病情严重程度及预后情况的临床价值。方法:选择2017年1月-2018年12月在本院诊治的120例慢性肺心病患者,根据患者呼吸循环功能状态分为缓解期58例(缓解期组)和急性加重期62例(急性加重期组),并选择同期在本院健康体检的健康人群60例作为健康对照组,患者入院后经2周对症治疗后,比较三组患者的血浆NT-proBNP、hs-CRP、动脉血二氧化碳分压(PaCO_(2))及氧分压(PaO_(2))水平变化情况,并采用Pearson直线相关性分析急性加重期患者血浆NT-proBNP、hs-CRP与PaCO_(2)、PaO_(2)的相关性。结果:急性加重期组患者的血浆NT-proBNP、hs-CRP及PaCO_(2)水平均明显高于缓解期组及健康对照组(P<0.05);急性加重期患者的PaO_(2)水平明显低于缓解期组及健康对照组(P<0.05);急性加重期患者治疗后血浆NT-proBNP、hs-CRP及PaCO_(2)水平较治疗前明显降低(P<0.05);PaO_(2)水平较治疗前明显升高(P<0.05);急性加重期患者血浆NT-proBNP、hs-CRP均与PaCO_(2)呈正相关性(r=0.867、0.936,P<0.05);与PaO_(2)呈负相关性(r=-0.685、-0.347,P<0.05)。结论:慢性肺心病急性加重期患者血浆NT-proBNP与hs-CRP水平可作为评估患者病情严重程度及预后情况的重要指标,临床动态监测有助于采取针对性治疗措施,控制病情进展,改善患者预后状况。Objective:To investigate the clinical value of arterial blood gas,detecting plasma N-terminal B-type natriuretic peptide(NT-proBNP)and hypersensitive CRP(hs-CRP)in patients with acute exacerbation of chronic cor pulmonale(CPD)in assessing the severity and prognosis of patients.Method:A total of 120 patients with chronic cor pulmonale who were treated in our hospital from January 2017 to December 2018 were divided into the remission group(58 cases)and acute exacerbation group(62 cases)according to their respiratory and circulatory function.A total of 60 healthy people who underwent physical examination in our hospital during the same period were selected as health control group.After 2 weeks of symptomatic treatment,the levels of NT-proBNP,hs-CRP,PaCO_(2) and PaO_(2) in plasma of three groups were compared,and the correlation between NT-proBNP,hs-CRP and PaCO_(2) and PaO_(2) in plasma of patients with acute exacerbation was analyzed by Pearson linear correlation.Result:The levels of NT-proBNP,hs-CRP and PaCO_(2) in patients with acute exacerbation were significantly higher than those in remission group and healthy control group(P<0.05);the levels of PaO_(2) in patients with acute exacerbation were significantly lower than those in remission group and healthy control group(P<0.05);the levels of NT-proBNP,hs-CRP and PaCO_(2) in patients with acute exacerbation after treatment lower than before treatment(P<0.05),the levels of PaO_(2) was higher than before treatment(P<0.05).The plasma NT-proBNP and hs-CRP were positively correlated with PaCO_(2)(r=0.867,0.936,P<0.05)and negatively correlated with PaO_(2)(r=-0.685,-0.347,P<0.05).Conclusion:The plasma NT-proBNP and hs-CRP levels in patients with acute exacerbation of chronic cor pulmonale can be used as important indicators to evaluate the severity and prognosis of patients.Clinical dynamic monitoring can help to take targeted treatment measures,control the progress of the disease and improve the prognosis of patients.

关 键 词：慢性肺心病 N末端B型利钠肽原 超敏CRP 

分 类 号：R541.5[医药卫生—心血管疾病]