Apo-A1/Apo-B、视黄醇结合蛋白与绝经后女性冠心病患者冠状动脉病变程度的关系  

The Relationship Between Apo-A1/Apo-B,Retinol Binding Protein and the Degree of Coronary Artery Disease in Postmenopausal Women with Coronary Heart Disease

作　　者：李雪兰 余永雄 LI Xue-lan;YU Yong-xiong(Department of Laboratory Medicine,Wuzhou Workers'Hospital,Wuzhou 543000,Guangxi,China;Department of Laboratory Medicine,Wuzhou Maternal and Child Health Hospital,Wuzhou 543000,Guangxi,China)

机构地区：[1]梧州市工人医院检验科,广西梧州543000 [2]梧州市妇幼保健院检验科,广西梧州543000

出　　处：《医学信息》2021年第11期181-183,共3页Journal of Medical Information

摘　　要：目的探讨血清载脂蛋白-A1/血清载脂蛋白-B(Apo-A1/Apo-B)、视黄醇结合蛋白(RBP)与绝经后女性冠心病患者冠状动脉病变程度的关系。方法选取2018年3月~2020年3月梧州市工人医院收治的绝经后冠心病患者87例作为研究组,行冠脉造影并通过Gensini积分评价患者冠状动脉病变程度。根据Gensini积分评分将研究组分为轻度病变组(38例),中度病变组(39例)与重度病变组(10例),根据冠脉病变支数分为单支病变组(38例)与多支病变组(49例),另选取同期在我院体检的50例健康绝经女性作为对照组,比较各组Apo-A1、Apo-B、Apo-A1/Apo-B与RBP水平,并通过Spearman分析其水平与患者冠状动脉病变程度的关系。结果单支病变组与多支病变组患者Apo-A1、Apo-A1/Apo-B低于对照组,Apo-B、RBP高于对照组(P<0.05),其中多支病变组Apo-A1、Apo-A1/Apo-B低于单支病变组,Apo-B、RBP高于单支病变组(P<0.05);病变组Apo-A1、Apo-A1/Apo-B均低于对照组,Apo-B、RBP高于对照组,并且病变程度越严重Apo-A1、Apo-A1/Apo-B水平越低,Apo-B、RBP越高;轻度、中度、重度病变组Apo-A1/Apo-B、RBP水平比较,差异有统计学意义(P<0.05);Spearman等级相关分析显示,Apo-A1/Apo-B水平与冠状病血管病变程度呈反比(r=-0.382,P<0.05),RBP水平与冠状病血管病变程度呈正比(r=-0.320,P<0.05)。结论绝经后女性冠心病患者Apo-A1/Apo-B呈低水平表达,RBP呈高水平表达,并且Apo-A1/Apo-B水平越低,患者冠状动脉病变程度越严重,RBP水平越高患者冠状动脉病变程度越轻。Objective To investigate the relationship between serum apolipoprotein-A1/serum apolipoprotein-B(Apo-A1/Apo-B),retinol binding protein(RBP)and the degree of coronary artery disease in postmenopausal women with coronary heart disease.Methods A total of 87 postmenopausal coronary heart disease patients admitted to Wuzhou Workers’Hospital from March 2018 to March 2020 were selected as the research group.Coronary angiography was performed and the degree of coronary artery disease was evaluated by Gensini score.According to the Gensini score,the study was divided into mild disease group(38 cases),moderate disease group(39 cases)and severe disease group(10 cases).According to the number of coronary artery diseased branches,they were divided into single-vessel disease group(38 cases)and multi-vessel disease group(49 cases).In addition,50 healthy menopausal women who received physical examination in our hospital during the same period were selected as the control group to compare the levels of Apo-A1,Apo-B,Apo-A1/Apo-B and RBP in each group.And analyzed the relationship between its level and the degree of coronary artery disease by Spearman.Results Apo-A1,Apo-A1/Apo-B in the single-vessel disease group and multiple-vessel disease group were lower than those in the control group,and Apo-B and RBP were higher than those in the control group(P<0.05).Among them,Apo-A1 and Apo-A1/Apo-B in the multivessel disease group were lower than those in the single-vessel disease group,and Apo-B and RBP were higher than those in the singlevessel disease group(P<0.05);Apo-A1 and Apo-A1/Apo-B in the diseased group were lower than those in the control group,and Apo-B and RBP were higher than those in the control group.And the more severe the disease,the lower the level of Apo-A1,Apo-A1/Apo-B,the higher the level of Apo-B and RBP;the comparison of the levels of Apo-A1/Apo-B and RBP in the mild,moderate,and severe disease groups,the difference was statistically significant(P<0.05);Spearman rank correlation analysis showed that the level of

关 键 词：血清载脂蛋白-A1 血清载脂蛋白-B 视黄醇结合蛋白 绝经后女性 冠心病 冠状动脉病变 

分 类 号：R541[医药卫生—心血管疾病]