预防性使用抗生素在婴幼儿先心病术后延迟关胸中的应用效果  

Application effect of prophylactic use of antibiotics on delayed sternal closure in infants with congenital heart disease after operation

作　　者：郭亚鹏 高宏 常瑛 张雅宁 张圣惠 赵堃 曾新艳 GUO Yapeng;GAO Hong;CHANG Ying;ZHANG Yaning;ZHANG Shenghui;ZHAO Kun;ZENG Xinyan(Heart Center,Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University Health Science Center,Xi'an 710003,China;Pharmacy Department,Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University Health Science Center,Xi'an 710003,China;Internal Medicine Department,Northwest Women's and Children's Hospital Affiliated to Xi'an Jiaotong University Health Science Center,Xi'an 710003,China)

机构地区：[1]西安交通大学医学部附属西北妇女儿童医院心脏中心,陕西西安710003 [2]西安交通大学医学部附属西北妇女儿童医院药剂科,陕西西安710003 [3]西安交通大学医学部附属西北妇女儿童医院内科,陕西西安710003

出　　处：《临床医学研究与实践》2021年第16期113-115,共3页Clinical Research and Practice

摘　　要：目的探讨婴幼儿先心病术后延迟关胸(delayed sternal closure,DSC)预防性使用抗生素的临床风险。方法回顾性分析本中心2015年1月至2019年6月的35例先心病术后DSC患儿预防性使用抗生素的临床资料。结果本研究共纳入35例患儿,6例(17.1%)持续使用常规抗生素预防(常规组),29例(82.9%)改用特殊抗生素预防(特殊组);两组的胸部切口感染发生率分别为16.7%(1/6)、6.9%(2/29),组间比较,差异无统计学意义(P>0.05)。8例(22.9%)患儿为短时间预防性使用抗生素(短时间使用组),27例(77.1%)患儿为延长时间预防性使用抗生素(延长使用组);两组的胸部切口感染发生率分别为12.5%(1/8)、7.4%(2/27),组间比较,差异无统计学意义(P>0.05)。结论先心病术后DSC的患儿选择特殊抗生素和延长使用抗生素均不会影响胸部切口感染的发生率,但可增加抗生素药物不良反应的发生风险。Objective To investigate the clinical risk of prophylactic use of antibiotics on delayed sternal closure(DSC)in infants with congenital heart disease after operation.Methods The clinical data of 35 children with congenital heart disease who were treated with prophylactic use of antibiotics after operation in our center from January 2015 to June 2019 were retrospectively analyzed.Results A total of 35 children were enrolled in this study.Six cases(17.1%)were continued to use conventional antibiotics for prevention(the conventional group),while 29 cases(82.9%)were switched to special antibiotics for prevention(the special group).The incidence of chest incision infection in the two groups were 16.7%(1/6)and 6.9%(2/29)respectively,and there was no significant difference between the two groups(P>0.05).Eight cases(22.9%)were treated with short-term prophylactic use of antibiotics(the short-term group),and 27 cases(77.1%)were treated with extended prophylactic use of antibiotics(the extended group).The incidence of chest incision infection in the two groups were 12.5%(1/8)and 7.4%(2/27)respectively,and there was no significant difference between the two groups(P>0.05).Conclusion For children with DSC in congenital heart disease after operation,the choice of special antibiotics and prolonged use of antibiotics will not affect the incidence of chest incision infection,but can increased the risk of adverse drug reactions.

关 键 词：婴幼儿 延迟关胸 抗生素 先天性心脏病 预防性使用 

分 类 号：R541[医药卫生—心血管疾病]