肺瘤消积方对痰瘀互结型非小细胞肺癌患者化疗不良反应的影响  

Effect of Feiliu Xiaoji Formula on adverse reactions of chemotherapy in patients with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome

作　　者：王振强 张庆江 陈晶晶 赵阳 李小江[2] 董雪珊 赵芳 李莹 WANG Zhenqiang;ZHANG Qingjiang;CHEN Jingjing;ZHAO Yang;LI Xiaojiang;DONG Xueshan;ZHAO Fang;LI Ying(Department of Internal Medicine,Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine,Cangzhou,Hebei 061000,China;Department of Oncology,The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China;Chengde Medical University,Chertgde,Hebei 067000,China;Graduate School,Hebei University of Chinese Medicine,Shijiazhuang,Hebei 050051,China)

机构地区：[1]河北中医学院附属沧州中西医结合医院中医内科,河北沧州061000 [2]天津中医药大学第一附属医院肿瘤科,天津300000 [3]承德医学院,河北承德067000 [4]河北中医学院研究生学院,河北石家庄050051

出　　处：《上海中医药杂志》2021年第4期45-49,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2019271)。

摘　　要：目的观察肺瘤消积方对痰瘀互结型非小细胞肺癌患者化疗不良反应的影响。方法将100例痰瘀互结型非小细胞肺癌患者随机分为治疗组和对照组,每组50例。两组均采用常规方案化疗,对照组视情况给予止呕、护肝、护胃治疗,治疗组在此基础上加用中药汤剂肺瘤消积方。两组疗程均为4个化疗周期,观察临床疗效及化疗不良反应的发生情况,比较中医证候积分、癌症患者生命质量测定量表(EORTC QLQ-C30)评分的变化情况。结果 (1)治疗组、对照组总有效率分别为86.00%、68.00%;组间临床疗效比较,差异有统计学意义(P<0.05)。(2)治疗组发生骨髓抑制、消化道反应、脱发、肝肾功能损害、外周神经毒性0度不良反应的病例数多于对照组,发生Ⅲ度、Ⅳ度上述不良反应的病例数少于对照组,差异有统计学意义(P<0.05)。(3)治疗前后组内比较,两组中医证候积分均降低(P<0.05);组间治疗后比较,治疗组中医证候积分低于对照组(P<0.05)。(4)治疗前后组内比较,两组EORTC QLQ-C30量表功能部分中的整体生活质量、躯体功能、情绪功能评分升高(P<0.05),症状部分中的疲乏、恶心呕吐、疼痛、睡眠障碍、食欲减退、便秘、腹泻评分降低(P<0.05);组间治疗后比较,整体生活质量、躯体功能、情绪功能、疲乏、恶心呕吐、睡眠障碍、食欲减退、便秘、腹泻评分差异有统计学意义(P<0.05)。结论肺瘤消积方与辅助化疗有协同作用,有助于提高痰瘀互结型非小细胞肺癌临床疗效,改善患者的生存质量,并减轻化疗不良反应。Objective To observe the effect of Feiliu Xiaoji Formula on adverse reactions of chemotherapy in patients with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome. Methods Totally 100 cases with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome were randomly divided into treatment group(n=50) and control group(n=50). Both groups were administered with conventional chemotherapy. The control group was treated with anti-vomiting, liver protection and stomach protection as appropriate, while the treatment group was additionally administered with Feiliu Xiaoji Formula besides symptomatic treatment. The course of treatment in both groups was 4 chemotherapy cycles. The clinical effect and incidence of adverse reactions of chemotherapy were observed, and the changes of TCM syndrome scores and Quality of Life Questionnaire Core 30 of EORTC(EORTC QLQ-C30) scores were compared. Results(1)The total effective rate of the treatment group was 86.00%, which was significantly higher than that of the control group(68.00%)(P<0.05).(2)The number of cases of bone marrow suppression(grade 0), digestive tract reaction, alopecia, liver and kidney function damage and peripheral neurotoxicity in the treatment group was more than that in the control group,but the number of cases with above adverse reactions( grade 3-4) in the treatment group was less than that in the control group,and the difference was statistically significant( P<0.05).(3) The TCM syndrome scores of both groups decreased after treatment( P<0.05) and the TCM syndrome scores of the treatment lower than the scores of the control group( P< 0.05).(4)By comparing the QLQ-C30 scores of the two groups before and after treatment,we found that in both groups the scores of overall quality of life,physical function and emotional function in the functional part increased after treatment( P<0.05),the scores of fatigue,nausea,vomiting,pain,sleep disorder,anorexia,constipation and diarrhea in the symptom part decreased after treatment( P

关 键 词：非小细胞肺癌 肺瘤消积方 痰瘀互结证 化疗 不良反应 

分 类 号：R273[医药卫生—中西医结合]