不同剂量丙种球蛋白联合光疗治疗ABO溶血患儿的疗效观察  

Effect of different doses of gamma globulin combined with phototherapy in treatment of children with ABO hemolysis

作　　者：黄强 郭华 杨光 HUANG Qiang;GUO Hua;YANG Guang(Department of Blood Transfusion,Shenzhen Longhua District People's Hospital,Shenzhen,518109,China)

机构地区：[1]深圳市龙华区人民医院输血科,广东深圳518109

出　　处：《临床血液学杂志》2021年第4期275-277,281,共4页Journal of Clinical Hematology

摘　　要：目的:探讨不同剂量丙种球蛋白联合光疗治疗ABO溶血患儿的疗效。方法:选取2018年2月—2019年6月在深圳市龙华区人民医院输血科收治的64例ABO溶血患儿为研究对象,按照随机抽样法分为对照组(给予小剂量丙种球蛋白联合光疗治疗)与观察组(给予大剂量丙种球蛋白联合光疗治疗)各32例,并对2组患者的临床总有效率、不良反应发生率、新生儿神经行为测定(NBNA)评分、前白蛋白(PA)、血红蛋白(Hb)、总胆汁酸(TBA)、总胆红素(TBiL)及黄疸消退时间、蓝光照射治疗时间、住院时间进行观察及评估。结果:观察组的总有效率高于对照组(χ^(2)=5.143,P<0.05)。治疗72 h后,观察组的NBNA评分、PA、Hb高于对照组,而TBA、TBiL低于对照组(P<0.05)。观察组的黄疸消退时间、蓝光照射治疗时间、住院时间短于对照组(P<0.05)。观察组不良反应发生率与对照组差异无统计学意义(χ^(2)=0.160,P>0.05)。结论:大剂量丙种球蛋白联合光疗治疗更能改善ABO溶血患儿的NBNA评分,降低血清TBA、TBiL水平。Objective:To explore the effect of different doses of gamma globulin combined with phototherapy in the treatment of children with ABO hemolysis.Methods:A total of 64 children with ABO hemolysis admitted to the Department of Blood Transfusion,People’s Hospital of Longhua District,Shenzhen from February 2018 to June 2019 were selected as the research subjects,and were divided into control groups according to random sampling method(given low-dose gamma globulin combined with phototherapy)and observation group(given high-dose gamma globulin combined with phototherapy),32 cases each,and the total clinical effective rate,adverse events rate,neonatal neurobehavioral measurement(NBNA)score,prealbumin(PA),hemoglobin(Hb),total bile acid(TBA),total bilirubin(TBiL)and time to jaundice resolution,blue light irradiation treatment time and hospital stay were observed and evaluated.Results:The total effective rate of the observation group was higher than that of the control group(χ^(2)=5.143,P<0.05).After 72 hours of treatment,the NBNA score,PA and Hb of the observation group were higher than those of the control group,while the TBA and TBiL were lower than those of the control group(P<0.05).The jaundice resolution time,blue light irradiation treatment time,and hospital stay of the observation group were shorter than those of the control group(P<0.05).The incidence of adverse events in the observation group was the same as that in the control group(χ^(2)=0.160,P>0.05).Conclusion:High-dose gamma globulin combined with phototherapy could better improve the NBNA score of children with ABO hemolysis,and reduce the levels of serum TBA and TBiL.

关 键 词：丙种球蛋白 光疗 ABO溶血 新生儿神经行为测定评分 总胆红素 

分 类 号：R722.18[医药卫生—儿科]