生物检材中常见除草剂的分析方法及研究进展  

Analysis Methods of Common Herbicides in Biological Material and Research Progress

作　　者：岳琳娜 向平 宋粉云 严慧 YUE Lin-na;XIANG Ping;SONG Fen-yun;YAN Hui(Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Ministry of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]司法鉴定科学研究院,上海市法医学重点实验室,司法部司法鉴定重点实验室,上海市司法鉴定专业技术服务平台,上海200063 [2]广东药科大学药学院,广东广州510006

出　　处：《法医学杂志》2021年第2期248-255,共8页Journal of Forensic Medicine

基　　金：上海市自然科学基金项目(19ZR1458800);上海市法医学重点实验室资助项目(17DZ2273200);司法部司法鉴定重点实验室资助项目;上海市司法鉴定专业技术服务平台资助项目(19DZ2292700)。

摘　　要：除草剂,是可以有效消灭或抑制杂草生长的一类化学或生物药剂。由于除草剂使用范围广、频率高,除草剂中毒时有报道。目前文献报道引起中毒的除草剂主要品种有百草枯、敌草快、草甘膦和草铵膦,其仪器分析方法主要为液相色谱-质谱法。本文综述了生物检材中常见除草剂的分析方法及应用的研究进展,总结生物检材中除草剂定性和定量分析的样品前处理、仪器分析情况,汇总实际中毒案例的检测数据,为除草剂中毒的临床诊治和司法鉴定提供参考。Herbicides are a kind of chemical or biological agents that can effectively destroy or inhibit weed growth.Because of the widespread and frequent use of herbicides,herbicide poisonings have often been reported.At present,the main species reported to have caused poisoning are paraquat,diquat,glypho-sate,and glufosinate.The main instrumental analysis method is LC-MS.This paper reviews the re-search progress on analysis methods of common herbicides in biological material and their application,summarizes the sample pretreatment and instrumental analysis situation of qualitative and quantitative analysis of herbicides in biological material,and collects test data of actual poisoning cases,to pro-vide reference for clinical diagnosis and treatment and forensic identification of herbicide poisoning.

关 键 词：法医毒理学 液相色谱-质谱法 除草剂 生物检材 综述 

分 类 号：DF795.1[医药卫生—法医学]