壳聚糖基水凝胶在伤口敷料中的应用  

Applications of chitosan-based hydrogel in wound dressings

作　　者：安占超 周末 金政[2,3] 赵凯 AN Zhanchao;ZHOU Mo;JIN Zheng;ZHAO Kai(Heilongjiang University Key Laboratory of Microbiology,College of Life Sciences,Heilongjiang University,Harbin 150080,China;College of Chemistry,Chemical Engineering and Materials,Heilongjiang University,Harbin 150080,China;Research and Development Department,Heilongjiang Kaizhenglihua Biological and Chemical Technology Company Limited,Harbin 150080,China)

机构地区：[1]黑龙江大学生命科学学院微生物黑龙江省高校重点实验室,哈尔滨150080 [2]黑龙江大学化学化工与材料学院,哈尔滨150080 [3]黑龙江凯正利华生物化工科技有限公司研发部,哈尔滨150080

出　　处：《黑龙江大学自然科学学报》2021年第2期195-202,共8页Journal of Natural Science of Heilongjiang University

基　　金：国家自然科学基金面上资助项目(31771000);黑龙江省杰出青年科学基金资助项目(JC2018008);黑龙江省省属高等学校基本科研业务费黑龙江大学专项资金项目(RCCXYJ201906);哈尔滨市“雏鹰计划”暨科技企业培育专项资助项目(2020CYJBCG0306)。

摘　　要：寻求促进创伤修复、具有优良性能的伤口敷料是研究的热点和难点。壳聚糖基水凝胶因具有良好的生物相容性、生物可降解性、止血、促进细胞增殖和组织再生等性能,在伤口愈合药物研发领域前景十分广阔。本文介绍了伤口敷料及其种类、壳聚糖水凝胶及其特性、壳聚糖基水凝胶的制备方法及其促进伤口愈合的功能特性;同时,对壳聚糖基水凝胶在伤口敷料中的应用进行了综述和展望。本文能为壳聚糖基水凝胶伤口敷料的相关研究提供一些借鉴,对开发性能优良的伤口敷料具有一定的参考价值。It is a hot and difficult research topic to search for wound dressings with excellent performance to promote wound repair.Chitosan-based hydrogel,because of its great biocompatibility,biodegradability,hemostasis,promotion of cell proliferation and tissue regeneration,has a broad prospect in the field of wound healing drug research and development.Wound dressings and their types,chitosan hydrogels and their characteristics,preparation methods of chitosan-based hydrogels and their functional properties to promote wound healing are introduced.At the same time,the application of chitosan-based hydrogels in wound dressings was reviewed and prospected.This paper can provide some reference for the related research of chitosan-based hydrogel wound dressings,and has certain reference value for the development of excellent wound dressings.

关 键 词：创伤修复 伤口敷料 壳聚糖 改性壳聚糖 水凝胶 

分 类 号：K826.15[历史地理—历史学]