幼儿急疹合并热性惊厥临床特点与致病因素分析  

Analysis of Clinical Characteristics and Pathogenic Factors of Exanthema Subitum with Febrile Seizures

作　　者：刘展 LIU Zhan(Department of Pediatrics,Beijing Mentougou District Hospital/Capital Medical University Mentougou Teaching Hospital,Beijing 102300,China)

机构地区：[1]北京市门头沟区医院/首都医科大学门头沟教学医院儿科,北京102300

出　　处：《医学信息》2021年第12期121-123,共3页Journal of Medical Information

摘　　要：目的探讨幼儿急疹合并热性惊厥临床发病特征及危险因素,为早期预防提供依据。方法回顾性分析2017年1月~2019年8月我院收治的456例幼儿急疹患儿临床资料,根据患儿是否合并热性惊厥分为合并热性惊厥组(n=84)和未合并热性惊厥组(n=372),比较两组临床特征、辅助检查结果、惊厥特点及危险因素。结果所有患儿均存在发热症状,高热65例(77.38%),典型特征为热退疹出;外周血白细胞<4.0×109/L 32例(38.10%),(4.0~9.5)×109/L 39例(46.43%),>9.5×109/L 13例(15.47%);合并热性惊厥84例,有家族史患儿73例(86.90%);单因素分析结果显示,两组年龄、性别、发热持续时间、出疹持续时间、单核细胞百分比比较,差异无统计学意义(P>0.05),最高体温、家族史比较,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,最高体温和家族史是热性惊厥患儿发病的独立危险因素(P<0.05)。结论所有幼儿急疹患儿均存在发热症状,且多为高热,最典型特征为热退疹出;对于幼儿急疹者体温高、存在家族史是其发生热性惊厥的危险因素,临床工作中应予以重视。Objective To explore the clinical characteristics and risk factors of exanthema subitemwith febrile seizures,and provide evidence for early prevention.Methods A retrospective analysis of the clinical data of 456 infants with exanthema subitem in our hospital from January 2017 to August2019.According to whether the children were combined with febrile convulsions,they were divided into a group with febrile convulsions(n=84)and a group without febrile convulsions(n=372).The clinical characteristics,auxiliary examination results,seizure characteristics and risk factors of the two groups were compared.Results All children had fever symptoms,65 cases(77.38%)had high fever,and the typical feature was fever and rash;Peripheral blood leukocytes<4.0×109/L 32 cases(38.10%),(4.0~9.5)×109/L 39 cases(46.43%),>9.5×109/L 13 cases(15.47%);There were 84 cases of febrile convulsions,and 73 cases(86.90%)of children with family history;The results of univariate analysis showed that there was no statistically significant difference between the two groups in age,gender,duration of fever,duration of rash,and percentage of monocytes(P>0.05).The difference in maximum body temperature and family history was statistically significant(P<0.05);The results of multivariate Logistic regression analysis showed that the highest body temperature and family history were independent risk factors for the onset of febrile seizures in children(P<0.05).Conclusion All children with exanthema subitem have fever symptoms,and most of them have high fever.The most typical feature is fever and rash;For children with exanthema subitem,high body temperature and family history are the risk factors for febrile seizures,which should be paid attention to in clinical work.

关 键 词：幼儿急疹 热性惊厥 外周血白细胞 

分 类 号：R720.597[医药卫生—急诊医学]