Synthesis of Well-defined Poly(tetrahydrofuran)-b-Poly(a-amino acid)s via Cationic Ring-opening Polymerization (ROP) of Tetrahydrofuran and Nucleophilic ROP of N-thiocarboxyanhydrides  

作　　者：Peng Zhou Xuan-Geng Dai Jie Kong Jun Ling 

机构地区：[1]Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China [2]Shaanxi Key Laboratory of Macromolecular Science and Technology,School of Chemistry and Chemical Engineering,Northwestern Polytechnical University,Xi'an 710072,China

出　　处：《Chinese Journal of Polymer Science》2021年第6期702-708,I0006,共8页高分子科学（英文版）

基　　金：Joint Foundation of Shaanxi Province Natural Science Basic Research Program and Shaanxi Coal Chemical Group Co.,Ltd.(No.2019JLM-46);the National Natural Science Foundation of China(No.21674091).

摘　　要：The synthesis of block copolymers of poly(tetrahydrofuran)-b-poly(α-amino acid)(PTHF-b-PAA)is challenging since it is difficult to combine the two blocks produced via different/conflicting ring-opening polymerization(ROP)mechanisms.In this contribution,the cationic ROP of THF is catalyzed by rare-earth triflate[RE(OTf)3]and terminated by 2-(t-butyloxycarbonyl-amino)ethanol(BAE).After the deprotection of t-butyloxycarbonyl(Boc)group,the chain end of PTHF is quantitatively changed to amino group which thereafter initiates the nucleophilic ROP ofα-amino acid N-thiocarboxyanhydrides(NTAs).Both polymerizations are well controlled,generating PTHF and PAA segments with designable molecular weights(MWs).PTHF-b-polylysine(PTHF-b-PLys)and PTHF-b-polysarcosine(PTHF-b-PSar)are obtained with MWs between 8.6 and 28.7 kg/mol.The above amphiphilic diblock copolymers form micelles in water.PTHF40-b-PSar32 acts as a surfactant to stabilize oil-in-water emulsions.Both segments of PTHF-b-PAA are biocompatible and promising in the biomedical application.

关 键 词：ANHYDRIDE polymerization CARBONYL 

分 类 号：TQ317[化学工程—高聚物工业] R318.08[医药卫生—生物医学工程]