化瘀消癥颗粒对盆腔炎性疾病后遗症中医证候评分及不同证型间炎症因子的影响  

Effect of Huayu Xiaozheng Granule on Traditional Chinese Medicine Syndrome Score and Inflammatory Factors among Different Syndrome Types of Sequelae of Pelvic Inflammatory Diseases

作　　者：黄艳茜 陈思[2] 袁烁[1] 邓高丕[1] HUANG Yanxi;CHEN Si;YUAN Shuo;DENG Gaopi(Department of Gynecology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510405,China;The First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院妇科,广东广州510405 [2]广州中医药大学第一临床医学院,广东广州510405

出　　处：《中国中医药现代远程教育》2021年第9期67-70,共4页Chinese Medicine Modern Distance Education of China

基　　金：广东省名中医邓高丕传承工作室【No.粤中医办函[2019]5号】;广州中医药大学一流学科研究重点项目【No.广中医校办[2020]62号】。

摘　　要：目的探讨化瘀消癥颗粒治疗盆腔炎性疾病后遗症(Pelvic inflammatory disease sequelae,SPID)的临床疗效。方法收集2018年1月—2019年11月广州中医药大学第一附属医院妇科门诊SPID90例,按照随机数字表法分为观察组和对照组,各45例。对照组口服血府逐瘀颗粒,观察组口服化瘀消癥颗粒,连续治疗14 d后评价临床疗效。对比患者治疗前后中医证候评分的变化情况、临床疗效及炎症因子的变化。结果观察组总有效率97.78%(44/45),对照组总有效率84.44%(38/45),2组差异有统计学意义(P<0.05)。在给药后第14天(节点2)、停药后7 d,观察组患者的中医证候总评分、白细胞计数、中性粒细胞百分比、超敏C反应蛋白、血清淀粉样蛋白A、盆腔积液改善程度均较对照组高,差异有统计学意义(P<0.05),湿热瘀结证比气虚血瘀证更为明显。结论化瘀消癥颗粒治疗SPID能降低中医证候总评分,快速改善临床症状,降低炎症因子指标,临床疗效确切。Objective To explore the clinical efficacy of Huayu Xiaozheng granul e in the treatment of sequela of pelvic inflammatory disease(SPID).Methods 90 patients with SPID in the gynecology clinic of the first affiliated Hospital of Guangzhou University of Chinese Medicine were randomly divided into observation group(n=45)and control group(n=45).The control group was treated with Xuefu Zhuyu granule orally,and the observation group was treated with Huayu Xiaozheng granule.The clinical effect was evaluated after continuous treatment for 14 days.The changes of traditional Chinese medicine syndrome score,clinical efficacy and inflammatory factors were compared before and after treatment.Results The total effective rate of the observation group was 97.78%(44/45),and the total effective rate of the control group was 84.44%(38/45),the difference between the two groups was statistically significant(P<0.05).At 14 days after administration(node 2)and 7 days after drug withdrawal(node 3),the total score of TCM syndrome,white blood cell count,percentage of neutrophils,hypersensitive C-reactive protein(hypersensitive CRP),serum amyloid protein A(SAA)and pelvic effusion improvement in the observation group were significantly higher than those in the control group,the difference between the two groups was statistically significant(P<0.05),and the syndrome of dampness-heat stasis was more obvious than that of qi deficiency and blood stasis.Conclusion Huayu Xiaozheng granule can reduce the total score of traditional Chinese medicine syndrome,quickly improve clinical symptoms and reduce the index of inflammatory factors in the treatment of SPID.

关 键 词：化瘀消癥颗粒 癥瘕 盆腔炎 后遗症 中医证候 炎症因子 

分 类 号：R271.9[医药卫生—中西医结合]