红细胞体积分布宽度和中性粒细胞与淋巴细胞比值联合预测糖尿病足的预后  

Red blood cell volume distribution width and neutrophil-to-lymphocyte ratio in prediction of prognosis of diabetic foot

作　　者：白超[1] 杨雯雯[2] 罗军[1] BAI Chao;YANG Wen-wen;LUO Jun(Department of Vascular and Thyroid Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China;不详)

机构地区：[1]新疆医科大学第一附属医院血管甲状腺外科,新疆乌鲁木齐830000 [2]新疆医科大学第二附属医院内分泌科,新疆乌鲁木齐830000

出　　处：《中国临床研究》2021年第5期596-599,共4页Chinese Journal of Clinical Research

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题项目(SKL-HIDCA-2018-15)。

摘　　要：目的探讨红细胞体积分布宽度(RDW)和中性粒细胞与淋巴细胞比(NLR)联合预测糖尿病足预后的价值。方法收集新疆医科大学第一附属医院2017年1月至2019年12月在血管甲状腺外科住院行截肢手术的糖尿病足100例患者的临床资料进行回顾性分析。按截肢平面分为大截肢组(踝关节以上,n=50)和小截肢组(踝关节及以下,n=50),分析术前NLR和RDW对截肢手术平面的预测效能。结果大截肢组患者术前NLR(9.81±2.09 vs 6.95±3.25,P<0.01)和RDW(14.02±2.87 vs 12.94±1.96,P<0.05)显著高于小截肢组。Logistic回归分析显示,术前高NLR和RDW水平是糖尿病足患者大截肢的独立危险因素(P<0.05)。ROC曲线分析显示,联合检测糖尿病足大截肢的AUC(0.79)大于NLR和RDW单项检测(0.77和0.59),敏感度、特异度(70.1%、71.8%)高于NLR和RDW单项检测(69.1%、68.3%和60.1%、61.2%)。结论糖尿病足患者术前NLR和RDW越高,行大截肢手术的可能性越大。术前NLR和RDW可能可以作为预测糖尿病足患者预后的指标。Objective To explore the value of red blood cell volume distribution width(RDW)and neutrophil to lymphocyte ratio(NLR)in predicting the prognosis of diabetic foot.Methods The clinical data of 100 patients with diabetic foot undergoing amputation in the First Affiliated Hospital of Xinjiang Medical University from January 2017 to December 2019 were collected and retrospectively analyzed.According to the amputation plane,the patients were divided into major amputation group(above the ankle joint,n=50)and minor amputation group(below the ankle joint,n=50).The predictive effectiveness of NLR and RDW on the amputation plane was evaluated.Results The preoperative NLR(9.81±2.09 vs 6.95±3.25,P<0.01)and RDW(14.02±2.87 vs 12.94±1.96,P<0.05)in major amputation group were significantly higher than those in minor amputation group.Logistic regression analysis showed that higher NLR and RDW were independent risk factors of major amputation(P<0.05).The AUC of the combined test(0.79)was greater than that of the NLR(0.77)and RDW(0.59)single test,and the sensitivity and specificity(70.1%,71.8%)were higher than that of the NLR(69.1%,68.3%)and RDW(60.1%,61.2%)single test.Conclusions The higher the preoperative NLR and RDW,the greater the possibility of major amputation in diabetic foot patients.Preoperative NLR and RDW may be used as prognostic indicators for the patients with diabetic foot.

关 键 词：糖尿病足 中性粒细胞与淋巴细胞比 红细胞体积分布宽度 截肢平面 

分 类 号：R587.2[医药卫生—内分泌]