颅骨朗格汉斯组织细胞增生症的临床特点及诊疗体会  

Clinical characteristics and diagnosis and treatment experiences of Langerhans cell histocytosis in skull

作　　者：尹国阳[1] 刘翠翠 肖以磊[1] 蒋海涛 许崇福[1] 高志宇[1] 祝子鹏[1] 杨凤海[1] 傅强[1] Yin Guoyang;Liu Cuicui;Xiao Yilei;Jiang Haitao;Xu Chongfu;Gao Zhiyu;Zhu Zipeng;Yang Fenghai;Fu Qiang(Department of Neurosurgery,Liaocheng People's Hospital,Liaoeheng 252000,China;Department of Breast Surgery,Liaocheng People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院脑科医院神经外科,252000 [2]聊城市人民医院两腺外科,252000

出　　处：《中华神经医学杂志》2021年第5期495-500,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81701159);山东省重点研发计划项目(2018GSF118046);中国博士后基金(2018M632123)。

摘　　要：目的探讨颅骨朗格汉斯组织细胞增生症(LCH)的临床特点及诊疗体会。方法回顾性分析聊城市人民医院脑科医院神经外科自2015年1月至2019年12月收治的16例颅骨LCH患者的临床资料、诊疗经过及预后。结果16例患者中男13例,女3例;年龄1~31岁;临床上均表现为颅骨占位性病变,影像学检查显示颅骨骨质破坏,合并或不合并其他骨骼或器官受累。所有患者均行手术完整切除肿物,术后病理证实为LCH。术后常规全身骨扫描发现1例局部异常代谢活跃,加行局部放疗;8例合并其他骨骼或器官受累者予联合化疗。随访1~5年,所有患者均未出现复发,且无一例死亡。结论颅骨LCH患者经积极手术后,根据术后复查结果再联合规范化放化疗,其预后可较好。Objective To analyze the clinical characteristics and diagnosis and treatment experiences of Langcrhans cell histocytosis(LCH)in skull.Methods Sixteen patients with cranial LCH admitted to our hospital from January 2015 to December 2019 were chosen in our study.Their clinical data,diagnosis and treatment procedures and prognoses were retrospectively analyzed.Results Among the 16 patients,there were 13 males and 3 females,aged from 1 to 31 years.The clinical manifestations included space-occupying lesions of the skull;and imaging showed bone destruction of the skull,with or without involvement of other bones or organs.All patients were pathologically confirmed to have LCH after surgical total resection of the lesions.Routine whole-body bone scanning was performed after surgery:one was found to have local ubnormul metabolic activity and received local radiotherapy;8 were combined with other bone or organ involvement,and received chemotherapy.All the patients were followed up for 1-5 years,and no recurrence was found,and no one died.Conclusion Good prognosis can be achieved in cranial LCH patients accepted resection by giving additional treatment according to the results of postoperative reexamination and combination use of standardized radiotherapy and chemotherapy.

关 键 词：朗格汉斯组织细胞增生症 颅骨 临床回顾 

分 类 号：R651.11[医药卫生—外科学]