急性百草枯中毒的预后因素探讨  

Prognostic factors of acute paraquat poisoning

作　　者：黄坤 杨一红 闫敏[1] HUANG Kun;YANG Yihong;YAN Min(Emergency Department,Fuyang People's Hospital,Fuyang Anhui 236000,China)

机构地区：[1]阜阳市人民医院急诊科,安徽阜阳236000

出　　处：《中国急救复苏与灾害医学杂志》2021年第5期533-535,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：安徽省医学会急诊临床研究项目(编号:KY2018014)。

摘　　要：目的探讨影响急性百草枯中毒患者预后的因素.方法选取2017年1月—2020年8月阜阳市人民医院急诊科收治的急性百草枯中毒患者80例为研究对象,根据出院时患者的病情将其分为生存组和死亡组.对比两组患者的基本临床信息及入院时的实验室检查结果,寻找影响急性百草枯中毒患者预后的因素.结果生存组患者摄入百草枯的剂量、采用血液净化治疗比例明显低于死亡组(P<0.05);生存组患者入院时白细胞(white blood cells,WBC)、丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、肌酸激酶(creatine kinase,CK)、乳酸脱氢酶(lactate dehydrogenase,LDH)、尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,CREA)及尿百草枯含量程度均明显低于死亡组(P<0.05).多因素分析显示摄入百草枯的剂量、WBC、AST、CREA及尿百草枯含量为导致患者死亡的独立危险因素(P<0.05).结论急性百草枯中毒患者摄入百草枯的剂量、WBC、AST、CREA及尿百草枯含量为影响患者预后的关键因素.Objective To explore the factors affecting the prognosis of acute paraquat poisoning.Methods 80 patients with acute paraquat poisoning were hospitalized and undenvent individualized treatments of which 27 survived(survival group)and 53 died(death group).The demographical data,basic clinical information,and the results of laboratory tests on admission of the two groups of patients were compared to find the factors affecting the prognosis of paraquat poisoning.Results The amount of paraquat intake and proportion of blood purification treatment in the survival group were both significantly lower than those in the death group(both P<0.05).On admission the white blood cells(WBC),alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatine kinase(CK),lactate dehydrogenase(LDH),blood urea nitrogen(BUN),creatinine(CREA),and urine paraquat content in the survival group were all significantly lower than those in the death group(all P<0.05).Multivariate analysis showed that the amount of paraquat intake,WBC,AST,CREA and urine paraquat content were independent risk factors for death(all P<0.05).Conclusion The amount of paraquat intake,WBC,AST,CREA and urine paraquat content in patients with acute paraquat poisoning are the key factors affecting the prognosis of acute paraquat poisoning.

关 键 词：急性百草枯中毒 危险因素 预后 

分 类 号：R595[医药卫生—内科学]