健脾生血片治疗缺铁性贫血临床效果的回顾性分析  

Retrospective Analysis and Summary on Efficacy of Jianpi Shengxue Tablet in the Treatment of Iron Deficiency Anemia

作　　者：黎金庆 丛龙皎 黎牧郴 石憧娈 刘文兰[3] 王文娟[3] 胡乃东[1] LI Jinqing;CONG Longjiao;LI Muchen;SHI Chongluan;LIU Wenlan;WANG Wenjuan;HU Naidong(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 101100,China;Chaoyang Hospital,Capital Medical University,Beijing 100020,China;School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China)

机构地区：[1]北京中医药大学东直门医院,北京101100 [2]首都医科大学附属北京朝阳医院,北京100020 [3]首都医科大学中医药学院,北京100069

出　　处：《世界中医药》2021年第8期1268-1273,共6页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81774176)——补肾生血药调控JAK2-STATs通路纠正造血细胞增殖-凋亡失衡改善化疗后骨髓抑制的机制研究。

摘　　要：目的:回顾性分析健脾生血片治疗缺铁性贫血的临床效果与不良反应。方法:选取2017年1月1日至2020年10月30日北京中医药大学东直门医院通州院区门诊初诊、并首次用健脾生血片治疗的缺铁性贫血患者200例作为研究对象,比较治疗前后不同复查时间的血常规、血清铁、总铁结合力、铁蛋白结果,主观症状改善状况和不良反应。健脾生血片用法为3片/次,3次/d,饭后口服。结果:治疗前血红蛋白浓度为(83.58±15.81)g/L(n=200),治疗2周为(103.40±12.60)g/L(n=74),升高24.3%,与治疗前比较P=0.0047;治疗4周血红蛋白浓度(111.9±19.4)g/L(n=47),接近正常。治疗6周血红蛋白浓度完全正常为(126.0±9.49)g/L(n=30),治疗8周时血红蛋白浓度为(130.7±7.95)g/L(n=23);红细胞体积逐渐增大,平均红细胞血红蛋白含量逐渐升高,平均红细胞血红蛋白浓度也逐渐恢复正常。铁代谢指标中总铁结合力逐渐下降,血清铁和铁蛋白浓度逐渐升高,与治疗前比较,治疗4周时这3个铁代谢指标均明显改善(P<0.01)。所有病例均在治疗1周内获得明显症状改善,不良反应发生率为3.5%(7/200),主要是胃肠道刺激症状。结论:健脾生血片是治疗缺铁性贫血的良好药物,能快速全面改善贫血症状和提升血红蛋白水平。Objective:To make a retrospective analysis and summary on the efficacy of Jianpi Shengxue Tablet in the treatment of iron deficiency anemia.Methods:A total of 200 patients with iron deficiency anemia who were admitted to Tongzhou Branch of Dongzhimen Hospital of Beijing University of Chinese Medicine from 1 January 2017 to 30 October 2020 were selected as the research objects.All these patients were given treatment with Jianpi Shengxue Tablet for the first time.Results of blood routine examination,serum iron concentration,total iron binding capacity and ferritin were compared before and after treatment at different dates.Subjective symptoms and adverse reactions were also described.Jianpi Shengxue Tablet was given orally after meals,3 tablets each time,3 times a day.Results:Hemoglobin level was 83.58±15.81 g/L(M±SD,n=200)before treatment,and 103.40±12.60 g/L(n=74)after 2 week′s treatment,with a 24.3%increase(P=0.0047).Hemoglobin concentration was 111.9±19.4 g/L(n=47)at 4th week after treatment,which was near normality;126.0±9.49 g/L(n=30)at 6th week with complete normality and 130.7±7.95 g/L(n=23)at 8th week.MCV,MCH and MCHC increased gradually after treatment.Serum total iron biding capacity decreased,serum iron and ferritin increased gradually,and were significantly different at the 4th week after treatment as compared with that before treatment(P<0.01).Subjective symptoms were improved 1 week from starting treatment among all the cases.The adverse events were mainly gastrointestinal irritation,occurring in 7/200 cases(3.5%).Conclusion:Jianpi Shengxue Tablet is quite effective and safe in the treatment of iron deficiency anemia,with rapid comprehensive improvement of anemia-related symptoms and increase of hemoglobin and red blood cell parameters.

关 键 词：缺铁性贫血 健脾生血片 治疗 中医中药 

分 类 号：R255.9[医药卫生—中医内科学]