Roles of bile acids in enteric virus replication  

作　　者：Fanzhi Kong Linda J.Saif Qiuhong Wang 

机构地区：[1]Center for Food Animal Health,Department of Animal Sciences,College of Food,Agricultural and Environmental Sciences,The Ohio State University,Wooster,OH,USA. [2]College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,No.5 Xinfeng Road,Sartu District,Daqing,China [3]Department of Veterinary Preventive Medicine,College of Veterinary Medicine,The Ohio State University,Columbus,OH,USA.

出　　处：《Animal Diseases》2021年第1期39-47,共9页动物疾病（英文）

基　　金：supported by state and federal funds appropriated to Ohio Agricultural Research and Development Center(OARDC),College of Food,Agricultural,&Environmental Sciences,The Ohio State University;supported by China Scholarship Council(201908230090).

摘　　要：Bile acids(BAs)are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients.In the intestines,where enteric viruses replicate,BAs also act as signaling molecules that modulate various biological functions via activation of specific receptors and cell signaling pathways.To date,BAs present either pro-viral or anti-viral effects for the replication of enteric viruses in vivo and in vitro.In this review,we summarized current information on biosynthesis,transportation and metabolism of BAs and the role of BAs in replication of enteric caliciviruses,rotaviruses,and coronaviruses.We also discussed the application of BAs for cell culture adaptation of fastidious enteric caliciviruses and control of virus infection,which may provide novel insights into the development of antivirals and/or disinfectants for enteric viruses.

关 键 词：Bile acids CORONAVIRUS CALICIVIRUS ROTAVIRUS NOROVIRUS SAPOVIRUS 

分 类 号：TU8[建筑科学]