基于古今医案云平台的抑郁症中医处方用药规律分析  

Research on the rules of Traditional Chinese Medicine prescriptions of depression based on Ancient and Modern Medical Records Cloud Platform

作　　者：莫嘉浩 梁浩锐 许洪彬 黄演芬 任芷萱 叶玉萍 吴倩[1] 徐福平 Mo Jiahao;Liang Haorui;Xu Hongbin;Huang Yanfen;Ren Zhixuan;Ye Yuping;Wu Qian;Xu Fuping(Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Pre-Treatment Center of Guangdong Traditional Chinese Medicine Hospital,Guangzhou 510120,China)

机构地区：[1]广州中医药大学,510405 [2]广州中医药大学第二附属医院广东省中医院治未病中心,510120

出　　处：《国际中医中药杂志》2021年第5期492-497,共6页International Journal of Traditional Chinese Medicine

基　　金：广东省中医药健康服务与产业发展研究中心(2019YBB06);广东省中医院治未病专项(YN2019ZWB03);广东省中医院名中医药专家学术经验传承工作室(中医二院﹝2014﹞89号-6)。

摘　　要：目的探究治疗抑郁症的药证关系与核心处方。方法检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)建库至2019年11月30日收录的中医治疗抑郁症相关期刊论文,以及古今医案云平台(V 1.5)中的国家级名中医工作室共享医案中的抑郁症医案,筛选抑郁症医案数据,用Excel 2010建立标准化医案数据库,规范饮片名后以古今医案云平台(V 1.5)系统集成的统计分析、关联规则分析、复杂网络等方法,分析医案的组方用药频次、药性、核心处方等。结果共纳入有效验案632个,涉及药物527味,共得到高频中药23种,使用频次最高者为柴胡;用药以温、平为主;药味以辛、甘、苦为多;归经以肺、肝、心、脾经为主;关联规则分析共得到药物关联规则25条,四诊信息-中药关联规则13条。结论中医治疗抑郁症多治以疏肝理气、清心安神,以柴胡、郁金、白芍、川芎、炒酸枣仁为基础方,予当归、麦冬、合欢皮、远志、茯苓等药作加减参考。Objective To explore the relationship between drug evidence and core prescription for depression.Methods We retrieved literature of TCM for depression from CNKI,VIP and Wangfang databases to November 2019,30th as well as there cords from Ancient and Modern Medical Records Cloud Platform(V 1.5).The Excel 2010 was used to establish the standardized database of medical records.After the standardization of medicines,Ancient and Modern Medical Records Cloud Platform(V1.5)statistics methodswere used for association rules analysis,complex networks,and analysis of drugs’frequency,medical characteristics,core prescription drugs.Results A total of 632 effective prescriptions were included,involving a total of 527 drugs.The results of frequency of herbs showed that 23 kinds of high-frequency herbs were obtained.Bupleuri Radix was the most frequently used medicine.Most herbs are warm or flat,with pungent,sweet and bitter in taste,belonging to the lung,liver,heart and spleen meridians.A total of 25 drug-pair association and 13 TCM association were obtained by association rule analysis.Conclusions TCM treatment for depression is mainly based on soothing the liver and regulating qi,clearing the heart and calming the nerves.Bupleuri Radix,Curcumae Radix,Paeoniae Radix Alba,Chuanxiong Rhizoma,Ziziphi Spinosae Semen are the basic prescriptions.Angelicae Sinensis Radix,Ophiopogonis Radix,Albiziae Cortex,Polygalae Radix,Poria are used as reference.

关 键 词：抑郁症 抗抑郁药(中药) 中医药疗法 数据挖掘 用药规律 古今医案云平台 

分 类 号：R249[医药卫生—中医临床基础] R277.7[医药卫生—中医学]