西洋参破壁饮片抗疲劳、耐缺氧、耐低温作用及急性毒性研究  

Study on Anti-fatigue, Anoxia-tolerant and Low-temperature-resistant Effects of Ultrafine Granular Powder of Panax Quinquefolium and its Acute Toxicity

作　　者：唐琳 梅全喜[3] 高玉桥[3] 林慧[3] 胡莹[3] 彭丽华 成金乐 TANG Lin;MEI Quanxi;GAO Yuqiao;LIN Hui;HU Ying;PENG Lihua;CHENG Jinle(ZhongshanZhongzhi Pharmaceutical Group Co.Ltd,Zhongshan,Guangdong 528437,China;Zhongshan Hengsheng Pharmaceutical Co.Ltd,Zhongshan,Guangdong 528411,China;Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Zhongshan,Guangdong 528401,China)

机构地区：[1]中山市中智药业集团有限公司,广东中山528437 [2]中山市恒生药业有限公司,广东中山528411 [3]广州中医药大学附属中山医院,广东中山528401

出　　处：《今日药学》2021年第4期280-283,共4页Pharmacy Today

基　　金：中山市科技计划项目(2017A1033);广东省中药破壁饮片工程实验室(粤发改创新函[2018]31(19)号);中药破壁饮片国家地方联合工程研究中心(发改办高技[2019]180号)。

摘　　要：目的考察西洋参破壁饮片抗疲劳、耐缺氧和耐低温的药效作用及急性毒性作用,为西洋参破壁饮片的安全有效应用提供参考。方法以传统饮片作为对照,分别采用小鼠负重游泳法、常压耐缺氧和耐低温试验方法观察西洋参破壁饮片的药效作用;采用最大给药量法观察西洋参破壁饮片的急性毒性。结果同等剂量的西洋参破壁饮片和1/2剂量的西洋参破壁饮片对小鼠抗疲劳和耐缺氧的作用比传统饮片更显著(P<0.05);1/4剂量和1/8剂量的西洋参破壁饮片抗疲劳和耐缺氧的作用与传统饮片相近;以最大给药量法对小鼠灌胃给药西洋参破壁饮片(剂量相当于其传统饮片临床用量的11~22倍),未出现急性毒性反应。结论西洋参破壁饮片比传统饮片具有更显著的抗疲劳、耐缺氧的作用,且未见毒副作用,本研究为西洋参破壁饮片的安全性和高效利用提供初步参考。OBJECTIVE To explore the pharmacogical effects and acute toxicity of ultrafine granular powder(UGP) of Panax quinquefolium, in order to provide the scientific evidence of its safety and effectivenessof anti-fatigue, anoxia-tolerant and low-temperature-resistant. METHODS The testing methods of weight-bearing swimming, hypoxia tolerance and low-temperature tolerance in mice were induced to investigate the pharmacogical effects of UGP of Panax quinquefolium compared with that of traditional decoction pieces(TDP). The maximum dose method was used to observe the acute toxicity of UGP of Panax quinquefolium. RESULTS Equal dose and 1/2 dose of UGP of Panax quinquefolium showedmore significant anti-fatigue and anoxia-tolerant effect than thatin TDP of Panax quinquefolium(P<0.05). 1/4 and 1/8 dose of UGP of Panax quinquefolium showed similar anti-fatigue and anoxia-tolerant effect to TDP. No acute toxic reaction was observed in mice which treated with UGP of Panax quinquefolium by MTD(the dose equivalent to 11-22 times of the clinical dose of DP). CONCLUSION Compared with TDP, UGP of Panax quinquefoliumare more significant anti-fatigue and anti-anoxia effects, and shows no toxic effect. The study provides a preliminary reference for the safety and efficient use of UGP of Panax quinquefolium.

关 键 词：西洋参破壁饮片 抗疲劳 耐缺氧 耐低温 急性毒性 

分 类 号：R99[医药卫生—毒理学]