罗氏411电化学发光仪在发病12h内AMI诊断中的应用价值  

Application value of Roche 411 electrochemiluminescence instrument in the diagnosis of AMI within 12 h of onset

作　　者：罗洁 Luo Jie(The Third People’s Hospital of Hefei,Hefei 230041,Anhui Province,China)

机构地区：[1]合肥市第三人民医院(安徽医科大学合肥第三临床学院),合肥230041

出　　处：《现代科学仪器》2021年第3期182-185,共4页Modern Scientific Instruments

摘　　要：目的通过心梗标志物分析罗氏411电化学发光仪在发病12h内急性心肌梗死(AMI)诊断中的应用价值。方法选取我院62例发病12h内AMI患者为研究对象(AMI组),并收集64例同期健康体检者相关资料(对照组),比较两组经罗氏411电化学发光仪检测的心梗标志物[氨基末端脑钠肽前体(NT-proBNP)、超敏肌钙蛋白T(hs-cTnT)、肌酸激酶同工酶(CK-MB)]差异,使用采用受试者工作曲线(ROC曲线)评估入院时血清NT-proBNP、hs-cTnT、CK-MB水平对AMI的诊断价值;根据62例AMI患者发病至入院时间分为发病时间≤6h组及发病时间>6h组,比较其入院时血清NT-proBNP、hs-cTnT、CK-MB水平差异,分析发病时间与入院时血清NT-proBNP、hs-cTnT、CK-MB水平的相关性。结果AMI组血清NT-proBNP、hs-cTnT、CK-MB水平均显著高于对照组(P<0.05)。经ROC曲线分析,发现入院时血清NT-proBNP、hs-cTnT、CK-MB水平对AMI均具有较高诊断价值(AUC=0.963、0.966、0.969,P<0.05),其截断值分别为265.10pg/ml、14.18ng/ml、4.77ng/ml。62例AMI患者发病时间≤6h组35例,发病时间>6h组27例,发病时间≤6h组入院时血清NT-proBNP、hs-cTnT、CK-MB水平均低于发病时间>6h组(P<0.05)。经Pearson相关性分析,发现入院时血清NT-proBNP、hs-cTnT、CK-MB水平与AMI患者发病时间呈显著正相关(r=0.328、0.379、0.392,P<0.05)。结论罗氏411电化学发光仪具有快速、灵敏等优点,可通过检测血清NT-proBNP、hs-cTnT、CK-MB水平,辅助临床诊断AMI。Objective To analyze the application value of Roche 411 electrochemiluminescence instrument in the diagnosis of acute myocardial infarction(AMI)within 12 h of onset by means of myocardial infarction markers.Methods 62 patients with AMI within 12 h of onset in our hospital were selected as the research subjects(AMI group),and related data of 64 healthy persons(control group)during the same period were collected.The myocardial infarction markers detected by Roche 411 electrochemiluminescence instrument[N-terminal pro-brain natriuretic peptide(NT-proBNP),high-sensitivity troponin T(hs-cTnT),creatine kinase isoenzyme(CK-MB)]were compared between the two groups.Receiver operating characteristic curve(ROC curve)was used to assess the levels of serum NT-proBNP,hs-cTnT and CK-MB at admission in the diagnosis of AMI.According to the time from onset to admission of 62 patients with AMI,they were divided into onset time<6h group and onset time>6h group.The levels of serum NT-proBNP,Hs-cTnT and CK-MB were compared at admission,and the correlation between onset time and levels of serum NT-proBNP,hs-cTnT and CK-MB at admission was analyzed.Results The levels of serum NT-proBNP,hs-cTnT and CK-MB in AMI group were significantly higher than those in control group(P<0.05).After ROC curve analysis,it was found that levels of serum NT-proBNP,hs-cTnT and CK-MB at admission had high diagnostic value on AMI(AUC=0.963,0.966,0.969,P<0.05),and their cut-off values were 265.10pg/ml,14.18ng/mland 4.77ng/ml respectively.Among 62 cases of patients with AMI,there were 35 cases in onset time<6h group and 27 cases in onset time>6h group.The levels of serum NT-proBNP,hs-cTnT and CK-MB in onset time<6h group were lower than those in onset time>6h group(P<0.05).Pearson correlation analysis showed that levels of serum NT-proBNP,hs-cTnT and CK-MB at admission were significantly positively correlated withonset time of patients with AMI(r=0.328,0.379,0.392,P<0.05).Conclusion Roche 411 electrochemiluminescence instrument has the advantages of rapidness

关 键 词：心肌梗死 电化学发光仪 NT-PROBNP hs-cTnT CK-MB 标志物 

分 类 号：R54[医药卫生—心血管疾病]