Feasibility and safety of “bridging” pancreaticogastrostomy for pancreatic trauma in Landrace pigs  

作　　者：Jian Feng Hang-Yu Zhang Li Yan Zi-Man Zhu Bin Liang Peng-Fei Wang Xiang-Qian Zhao Yong-LiangChen 

机构地区：[1]Department of Hepatopancreatobiliary Surgery,Peking University Shougang Hospital,Beijing 100144,China [2]Faculty of Hepato-Pancreato-Biliary Surgery,Institute of Hepatobiliary Surgery of Chinese PLA,Key Laboratory of Digital Hepetobiliary Surgery,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《World Journal of Gastrointestinal Surgery》2021年第5期419-428,共10页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND In recent years,we created and employed a new anastomosis method,“bridging”pancreaticogastrostomy,to treat patients with extremely severe pancreatic injury.This surgery has advantages such as short length of surgery,low secondary trauma,rapid construction of shunts for pancreatic fluid,preventing second surgeries,and achieving good treatment outcomes in clinical practice.However,due to the limited number of clinical cases,there is a lack of strong evidence to support the feasibility and safety of this surgical procedure.Therefore,we carried out animal experiments to examine this procedure,which is reported here.AIM To examine the feasibility and safety of a new rapid method of pancreaticogastrostomy,“bridging”pancreaticogastrostomy.METHODS Ten Landrace pigs were randomized into the experimental and control groups,with five pigs in each group.“Bridging”pancreaticogastrostomy was performed in the experimental group,while routine mucosa-to-mucosa pancreaticogastrostomy was performed in the control group.After surgery,the general condition,amylase levels in drainage fluid on Days 1,3,5,and 7,fasting and 2-h postprandial blood glucose 6 mo after surgery,fasting,2-h postprandial peripheral blood insulin,and portal vein blood insulin 6 mo after surgery were assessed.Resurgery was carried out at 1 and 6 mo after the former one to examine the condition of the abdominal cavity and firmness and tightness of the pancreaticogastric anastomosis and pancreas.RESULTS After surgery,the general condition of the animals was good.One in the control group did not gain weight 6 mo after surgery,whereas significant weight gain was present in the others.There were significant differences on Days 1 and 3 after surgery between the two groups but no differences on Days 5 and 7.There were no differences in fasting and 2-h postprandial blood glucose and fasting and 2-h insulin values of postprandial peripheral blood and portal vein blood 6 mo after surgery between the two groups.One month after surgery,the sinus tract

关 键 词：Pancreatic trauma Damage control surgery “Bridging”pancreaticogastrostomy Severe pancreatic injury SAFETY 

分 类 号：R657.5[医药卫生—外科学]