Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring  

作　　者：Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang 

机构地区：[1]State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,Beijing 100193,People’s Republic of China [2]Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety,Hubei Key Laboratory of Animal Nutrition and Feed Science,Wuhan Polytechnic University,Wuhan 430023,People’s Republic of China [3]Department of Animal Science,Texas A&M University,College Station,TX 77843,USA [4]State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,Institute of Quality and Standard for Agro-products,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,People’s Republic of China [5]Key Laboratory of Agrifood Safety and Quality,Institute of Quality Standards and Testing Technology for Agricultural Products,Chinese Academy of Agricultural Sciences,Ministry of Agriculture and Rural Affairs,Beijing 100081,People’s Republic of China

出　　处：《Journal of Animal Science and Biotechnology》2021年第2期649-660,共12页畜牧与生物技术杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(31630074,31422052,31972596,31902189,31902170);the Beijing Municipal Natural Science Foundation(S170001);the China Agriculture Research System(CARS-35),the 111 Project(B16044);the Jinxinnong Animal Science Developmental Foundation,State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products(2018KLGM03);China Postdoctoral Science Foundation(2018 M630235)。

摘　　要：Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions.

关 键 词：Absorption DIGESTION FERMENTATION IUGR pigs Portal vein 

分 类 号：S828[农业科学—畜牧学]