含钆对比剂的环境污染现状、毒性及分析方法  

Current Environmental Situation,Toxicity and Analytical Methods of Gadolinium-based Contrast Agents

作　　者：刘洪涛 陈曦 沈素云 蒋超 冯顺卿 栾天罡[2] LIU Hong-tao;CHEN Xi;SHEN Su-yun;JIANG Chao;FENG Shun-qing;LUAN Tian-gang(Instrumental Analysis and Research Center,Sun Yat-sen University,Guangzhou 510275,China;School of Life Science,Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]中山大学测试中心,广东广州510275 [2]中山大学生命科学学院,广东广州510275

出　　处：《分析测试学报》2021年第6期876-884,共9页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(41271505,21625703)。

摘　　要：随着医疗技术的发展,药品和个人护理产品(PPCPs)因其在全世界范围内的大量使用,受到了越来越多的关注,含钆对比剂(GBCAs)可归属于这类化学品。许多造影剂在医疗诊断中被广泛使用以提高医学成像质量,大量的造影剂经生产、使用等过程释放至环境,成为新型环境污染物,对环境及生态造成影响,其中含钆对比剂便是其中一大类。GBCAs在体内几乎无代谢,而废水处理厂的传统工艺无法将其有效去除,造成该类物质进入水环境中,存在潜在环境风险。该文综述了目前含钆对比剂的分类、环境污染、生物毒性研究现状及分析检测方法,可为含钆对比剂的风险评价研究提供参考。Pharmaceuticals and personal care products(PPCPs)have received increasing attention due to their large amount of usage throughout the world as well as the comparable quantities introduced into the environment with“priority”pollutants.Meanwhile,gadolinium-based contrast agents(GBCAs)might belong to this class of chemicals.As a result of high doses of GBCAs administered in magnetic resonance imaging(MRI)exams,their unmetabolized excretion,and insufficient removal in wastewater treatment plants(WWTPs),large amounts of GBCAs are released into environment.Some of them have shown potential physiological toxicity and neurotoxicity.In this paper,the characteristics,exact classification,current environmental situation,and the analysis methods of GBCAs are reviewed,which might provide a reference for the risk assessment on GBCAs in the future.

关 键 词：药品和个人护理用品 含钆对比剂 分析方法 环境污染现状 毒性 

分 类 号：O657[理学—分析化学] X132[理学—化学]