聚ε-己内酯(PCL)小口径人造血管在动物实验中的内皮化研究现状  

Research Status of Endothelialization of Poly(ε-caprolactone)Small-Caliber Vascular Graft Implanted in Animals

作　　者：杨佳丽 陆金燕 张伟宸 邓小燕[1,2] 康红艳[1,2] YANG Jiali;LU Jinyan;ZHANG Weichen;DENG Xiaoyan;KANG Hongyan(Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science&Medical Engineering,Beihang University,Beijing 100083,China;Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing 100083,China)

机构地区：[1]北京航空航天大学生物与医学工程学院,生物力学与力生物学教育部重点实验室,北京100083 [2]北京航空航天大学生物医学工程高精尖创新中心,北京100083

出　　处：《医用生物力学》2021年第2期317-323,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11772036,31870940)。

摘　　要：体内植入人造血管后所面临的最严重的问题就是血管内血栓形成。为了解决这一问题,多年来科学界进行各种尝试,然而解决血栓形成使血管保持长期通畅的根本方法是实现内皮化。聚ε-己内酯[poly(ε-caprolactone),PCL]凭借其可生物降解、成本低、具备良好的力学性能等优势,近年来广泛应用于组织工程支架、药物输送等。主要针对PCL小口径人造血管植入不同动物模型后,以及同种动物模型不同植入条件下的内皮化情况展开论述,从动物模型、移植物不同的内皮化方式等角度找到小口径人造血管目前在临床应用中依旧不理想的原因,为以后动物模型的选择提供参考依据。The most serious problem facing the implantation of vascular graft in the body is the formation of blood clots.In order to solve this problem,various attempts have been made by the scientific community for many years.However,endothelialization is the fundamental method to solve thrombosis and keep vascular graft open for a long time.Poly(ε-caprolactone)(PCL)has the advantages of biodegradability,low cost and good mechanical properties.In recent years,it has been widely used as tissue engineering scaffolds,drug deliverys and so on.This article mainly reviews the endothelialization of small-caliber vascular graft based on PCL after implanted in different animal models,as well as the endothelialization of the same animal model but under different implantation conditions,and trying to find the reasons why small-caliber vascular grafts are still not ideal in clinical applications at different angles such as the different animal models and the different way about endothelialization,and provide references for future animal model selection.

关 键 词：聚Ε-己内酯 小口径人造血管 动物模型 内皮化 

分 类 号：R318.01[医药卫生—生物医学工程]