小青龙汤透皮疗法治疗风寒闭肺型小儿毛细支气管炎临床研究  

Clinical Study on Penetration Therapy with Modified Xiaoqinglong Tang for Children Bronchiolitis of Wind-Cold Fettering Lung Type

作　　者：杨虎明 袁晴丹 毕美芬 YANG Huming;YUAN Qingdan;BI Meifen

机构地区：[1]宁波市镇海区中医医院儿科,浙江宁波315200

出　　处：《新中医》2021年第8期26-29,共4页New Chinese Medicine

摘　　要：目的:观察小青龙汤透皮治疗对风寒闭肺型小儿毛细支气管炎的临床疗效。方法:将风寒闭肺型毛细支气管炎患儿98例按随机数字表法分成对照组和观察组各49例。对照组给予综合对症治疗,观察组在对照组的基础上给予小青龙汤透皮治疗。治疗2周后,比较2组治疗前后中医证候积分、血清免疫球蛋白A(IgA)、血清免疫球蛋白G(IgG)、血清免疫球蛋白M(IgM)及炎症因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平。结果:治疗后,2组咳嗽、泛吐痰涎、咽赤口干、喘憋气促、烦躁发热等证候积分均较治疗前降低(P<0.05),且观察组各项积分低于对照组(P<0.05)。治疗后,2组IgA、IgG水平均较治疗前升高(P<0.05),且观察组IgA、IgG水平高于对照组(P<0.05);而2组IgM水平治疗前后变化不大(P>0.05)。治疗后,2组IL-6、IL-8、TNF-α水平均较治疗前降低(P<0.05),且观察组各项指标低于对照组(P<0.05)。结论:小青龙汤透皮治疗风寒闭肺型小儿毛细支气管炎,可有效改善患儿发热、咳喘等临床症状,增加机体免疫力,改善炎症因子水平。Objective:To observe the clinical effect of penetration therapy with modified Xiaoqinglong tang for children bronchiolitis of wind-cold fettering the lung type.Methods:A total of 98 cases of children with bronchiolitis of wind-cold fettering the lung type were divided into the control group and the observation group according to the random number table method,49 cases in each group.The control group was treated with comprehensive and symptomatic treatment,and the observation group was additionally treated with penetration therapy with modified Xiaoqinglong tang based on the treatment of the control group.After two-week treatment,Chinese medicine syndrome scores and levels of immunoglobulins A(IgA),immunoglobulins G(IgG),immunoglobulins M(IgM)before and after treatment were compared between the two groups.Levels of inflammatory cytokines,namely,interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)before and after treatment were compared between the two groups.Results:After treatment,syndrome scores of cough,excessive excretion of phlegm and drool,redness of pharynx and dry mouth,asthma and panting,and agitation and fever in the two groups were decreased when compared with those before treatment(P<0.05),and each score in the observation group was lower than that in the control group(P<0.05).After treatment,levels of IgA and IgG in the two groups were increased when compared with those before treatment(P<0.05),and the two levels in the observation group were higher than those in the control group(P<0.05);levels of IgM in the two groups did not change much before and after treatment(P>0.05).After treatment,levels of IL-6,IL-8 and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and each index in the observation group was lower than that in the control group(P<0.05).Conclusion:In the treatment of children bronchiolitis of wind-cold fettering the lung type,penetration therapy with modified Xiaoqinglong tang can effectively improve clinical symptoms,such as f

关 键 词：小儿毛细支气管炎 风寒闭肺型 小青龙汤 透皮治疗 免疫球蛋白 炎症因子 

分 类 号：R725.6[医药卫生—儿科]