益气通脉解毒方治疗心肌梗死疗效观察及对血管新生指标的影响  

Curative Effect of Yiqi Tongmai Jiedu Prescription on Myocardial Infarction and Its Effect on Angiogenesis Indexes

作　　者：王贞 张志国[2] 张君[3] WANG Zhen;ZHANG Zhiguo;ZHANG Jun

机构地区：[1]河南省直属机关第一门诊部高血压科,河南郑州450003 [2]河南中医药大学第三附属医院心血管内科,河南郑州450003 [3]河南中医药大学针灸系,河南郑州450003

出　　处：《新中医》2021年第8期47-50,共4页New Chinese Medicine

基　　金：河南省中医管理局国家中医临床研究基地科研专项项目(2018JDZX101)。

摘　　要：目的:观察益气通脉解毒方对心肌梗死患者的疗效及患者体内血管新生指标的影响。方法:将心肌梗死患者96例,分为2组。对照组给予常规对症治疗,观察组在对照组基础上给予益气通脉解毒方治疗,分析2组患者治疗后的临床疗效。结果:2组治疗前血管新生指标、炎症因子水平组间比较,差异无统计学意义(P>0.05)。观察组治疗后血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平高于对照组,内皮素(ET)、高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。2组治疗前左心室射血分数、心肌梗死面积组间比较,差异无统计学意义(P>0.05)。观察组治疗后左心室射血分数(65.96±4.85)%高于对照组,心肌梗死面积(26.85±3.11)%低于对照组(P<0.05)。观察组总有效率(95.83%)高于对照组(83.33%),差异有统计学意义(P<0.05)。结论:益气通脉解毒方可促进心肌梗死患者血管新生,建立侧支循环,减轻炎症反应,缩小梗死面积。Objective:To observe the curative effect of Yiqi Tongmai Jiedu prescription on patients with myocardial infarction and its effect on angiogenesis indexes.Methods:A total of 96 patients with myocardial infarction were divided into two groups.The control group was given conventional symptomatic treatment,and the observation group was additionally given Yiqi Tongmai Jiedu prescription based on the treatment of the control group.The clinical effect in the two groups was analyzed after treatment.Results:There was no significant difference in the comparison of the angiogenesis indexes and inflammatory cytokines between the two groups before treatment(P>0.05).After treatment,the levels of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in the observation group were higher than those in the control group,and the levels of endothelin(ET),high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the comparison of the left ventricular ejection fraction and myocardial infarction area between the two groups(P>0.05).After treatment,the left ventricular ejection fraction(65.96±4.85)%in the observation group was larger than that in the control group and the myocardial infarct area(26.85±3.11)%was smaller than that in the control group(P<0.05).The total effective rate was 95.83%in the observation group,higher than that of 83.33%in the control group,the difference being significant(P<0.05).Conclusion:Yiqi Tongmai Jiedu prescription can promote angiogenesis,establish collateral circulation,lessen inflammation and reduce infarct area in patients with myocardial infarction.

关 键 词：心肌梗死 益气通脉解毒方 炎症反应 血管新生 

分 类 号：R542.22[医药卫生—心血管疾病]