滋肾柔经汤对痛风性肾病合并肾衰竭患者肾小管损伤与微炎症状态的影响  

Effect of Zishen Roujing Tang on Renal Tubular Injury and Micro-Inflammatory State in Patients with Gouty Nephropathy Complicated with Renal Failure

作　　者：夏松青 李楠 李志强 郝巧芳 侯小静 XIA Songqing;LI Nan;LI Zhiqiang;HAO Qiaofang;HOU Xiaojing

机构地区：[1]河南誉美肾病医院中医肾内科,河南鹤壁456750 [2]郑州市中医院肾病风湿科,河南郑州450007

出　　处：《新中医》2021年第8期70-74,共5页New Chinese Medicine

摘　　要：目的:探讨研究滋肾柔经汤对痛风性肾病合并肾衰竭患者肾小管损伤与微炎症状态影响及治疗效果。方法:纳入102例痛风性肾病合并肾衰竭患者为研究对象,依据治疗方式不同将患者分为观察组和对照组各51例,对照组采取基础治疗,观察组在对照组基础上采用滋肾柔经汤治疗。记录2组患者治疗效果、白蛋白(Alb)、血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)、β2-微球蛋白(β2-MG)、24 h尿蛋白定量(24 hUpro)、α1-微球蛋白(α1-MG)、肾小球滤过率(eGFR)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和单核细胞趋化蛋白-1(MCP-1)水平。结果:治疗前,2组Alb、UA、SCr、BUN比较,差异无统计学意义(P>0.05);治疗后,2组UA、SCr、BUN均降低,Alb升高,差异有统计学意义(P<0.05),且观察组UA、SCr、BUN低于对照组,Alb高于对照组,差异有统计学意义(P<0.05)。治疗前,2组eGFR、24 h Upro、α1-MG、β2-MG比较,差异无统计学意义(P>0.05);治疗后,2组24 h Upro、α1-MG、β2-MG均降低,eGFR升高,差异有统计学意义(P<0.05),且观察组24 h Upro、α1-MG、β2-MG低于对照组,eGFR高于对照组,差异有统计学意义(P<0.05)。治疗前,2组MCP-1、TNF-α、IL-6、hs-CRP比较,差异无统计学意义(P>0.05);治疗后,2组患者MCP-1、TNF-α、IL-6、hs-CRP均下降,且观察组MCP-1、TNF-α、IL-6、hs-CRP低于对照组,差异有统计学意义(P<0.05)。观察组总有效率88.24%,高于对照组66.67%,差异有统计学意义(P<0.05)。结论:滋肾柔经汤可减轻痛风性肾病合并肾衰竭患者肾小管损伤,明显改善患者微炎症状态,提高治疗效果。Objective:To discuss and study the effect of Zishen Roujing tang on renal tubular injury and micro-inflammatory state in patients with gouty nephropathy complicated with renal failure and its curative effect.Methods:A total of 102 cases of patients with gouty nephropathy complicated with renal failure were enrolled as the study objects,and divided into the observation group and the control group based on different treatment methods,51 cases in each group.The control group was given basic treatment,and the observation group was additionally given Zishen Roujing tang based on the treatment of the control group.The curative effect was recorded in the two groups.Levels of albumin(Alb),serum creatinine(SCr),blood urea nitrogen(BUN),urea nitrogen(UA),β2-microglobulin(β2-MG),24-hour urine protein quantification(24 hUpro),α1-microglobulin(α1-MG),estimated glomerular filtration rate(eGFR),hypersensitivity C-reaction protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and monocyte chemotactic protein-1(MCP-1)were recorded in the two groups.Results:Before treatment,when compared levels of Alb,UA,SCr,and BUN between the two groups(P>0.05).After treatment,levels of UA,SCr,and BUN in the two groups were decreased,and level of Alb was increased(P<0.05).After treatment,levels of UA,SCr,and BUN in the observation group were lower than those in the control group,and level of Alb was higher than that in the control group(P<0.05).Before treatment,when compared levels of eGFR,24 hUpro,α1-MG,andβ2-MG between the two groups(P>0.05).After treatment,levels of 24 hUpro,α1-MG,andβ2-MG in the two groups were decreased,and level of eGFR was increased(P<0.05).After treatment,levels of 24 hUpro,α1-MG,andβ2-MG in the observation group were lower than those in the control group,and level of eGFR was higher than that in the control group(P<0.05).Before treatment,when compared levels of MCP-1,TNF-α,IL-6,and hs-CRP between the two groups(P>0.05).After treatment,levels of MCP-1,TNF-α,IL-6,and hs-CRP in the two groups wer

关 键 词：痛风性肾病 肾衰竭 滋肾柔经汤 肾小管损伤 微炎症状态 

分 类 号：R692[医药卫生—泌尿科学]