受体相互作用蛋白的功能及在硬骨鱼类中的研究进展  

The Function of Receptor-interacting Protein(RIP)Kinases and the Research Progress in Teleost Fish

作　　者：李凯晴 李莹[2] 王艺磊[3] 邹鹏飞[3] LI Kai-qing;LI Ying;WANG Yi-lei;ZOU Peng-fei(College of the Environment&Ecology,Xiamen University,Xiamen 361102;Key Laboratory of Estuarine Ecological Security and Environmental Health,Tan Kah Kee College,Xiamen University,Zhangzhou 363105;Key Laboratory of Healthy Mariculture for the East China Sea,Ministry of Agriculture and Rural Affairs,Fisheries College,Jimei University,Xiamen 361021)

机构地区：[1]厦门大学环境与生态学院,厦门361102 [2]河口生态安全与环境健康福建省高校重点实验室厦门大学嘉庚学院,漳州363105 [3]农业农村部东海海水健康养殖重点实验室集美大学水产学院,厦门361021

出　　处：《生物技术通报》2021年第5期197-211,共15页Biotechnology Bulletin

基　　金：国家自然科学基金面上项目(31772878);福建省自然科学基金杰出青年科学基金项目(2018J06008)。

摘　　要：受体相互作用蛋白(RIP)是介导细胞死亡信号和炎症反应的关键调节因子,在调节免疫反应和维持机体稳态方面起着至关重要的作用。RIP在哺乳动物中参与了细胞死亡、炎症反应、先天免疫等不同的生物学过程,而鱼类作为重要的脊椎动物类群,关于RIP在鱼类中的功能我们仍然所知有限。因此,主要综述了RIP家族成员的分子结构、介导的信号通路和作用机制,以及其在硬骨鱼类中的研究进展,旨为深入解析鱼类乃至哺乳动物的免疫反应和抗病机制奠定基础。Receptor-interacting protein(RIP)kinases are key regulators that mediate cell death signals and inflammatory responses,and play vital roles in regulating immune responses and maintaining organism homeostasis.RIP kinases are involved in different biological processes such as cell death,inflammatory responses,and innate immunity in mammals.However,fish is an important group of vertebrates and our knowledge about the function of RIP kinases in fish is still limited.Therefore,this article mainly reviews the molecular structure,mediated signaling pathways and mechanisms of RIP family members,as well as the research progress of that in teleost fish,aiming to lay a foundation for deeply understanding immune responses and resistance mechanisms in fish as well as in mammals.

关 键 词：受体相互作用蛋白 先天免疫 细胞死亡 炎症反应 

分 类 号：S917.4[农业科学—水产科学]