氨基酸分子水溶液的太赫兹无损检测  

Terahertz spectral nondestructive detection of amino acid molecules in aqueous solution

作　　者：施卫[1] 王海青 侯磊[1] 董陈岗[1] 杨磊 赵红卫 王志全 王悦政 李超凡 SHI Wei;WANG HaiQing;HOU Lei;DONG ChenGang;YANG Lei;ZHAO HongWei;WANG ZhiQuan;WANG YueZheng;LI ChaoFan(Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi,School of Science,Xi'an University of Technology,Xi’an 710048,China;Shanghai Institute for Advanced Study,Chinese Academy of Sciences,Shanghai 201210,China)

机构地区：[1]西安理工大学理学院,陕西省超快光电技术与太赫兹科学重点实验室,西安710048 [2]中国科学院上海高等研究院,上海201210

出　　处：《中国科学：物理学、力学、天文学》2021年第5期86-91,共6页Scientia Sinica Physica,Mechanica & Astronomica

基　　金：国家自然科学基金(编号:61427814,61575161);国家重点基础研究发展计划(编号:2017YFA0701005);陕西省自然科学基金(编号:2019JZ-04);陕西省超快光电子技术与太赫兹科学重点实验室(编号:2018SZS-06);西安市超快光电器件技术重点实验室(编号:201805055ZD6-CG39)资助项目。

摘　　要：大多数生物分子在液体环境中才能维持其生物活性,实现液态生物分子的太赫兹(THz)光谱检测对活性生物分子的功能与结构.无创性生物医学检测的研究具有重要的应用价值.本文利用铌酸锂(LiNbO_(3))光整流产生的THz辐射,结合喇叭形渐变平行平板波导的局域电场增强效应,构建了可以检测微量活细胞和含水生物分子的THz时域光谱测量系统,实现了对4-氨基苯甲酸(4-Aminobenzoic Acid)及谷氨酸(Glutamic Acid)溶液的THz光谱检测.结果表明,去除水对THz波吸收的影响,4-氨基苯甲酸以及谷氨酸水溶液在0.1-2.0 THz频段有明显且独特的特征吸收峰.THz频段内的氨基酸水溶液特征吸收谱的获取为活性生物大分子或组织的检测奠定了基础.Only in liquid environment can most biomolecules maintain their biological activity,the realization of terahertz(THz)spectrum detection of water-bearing biomolecules has an important application value for the research of the function and structure of active biomolecules and non-invasive biomedical detection.In this paper,by using the THz radiation source generated by Li Nb O_(3) light rectification,and combing with the local electric field enhancement effect of the flared gradient parallel flat waveguide,we have built a THz time domain spectral measurement system that can detect the trace amounts of living cells and aqueous biomolecules,which can implement THz spectral detection of 4-aminobenzoic acid and glutamic acid in solution.The results show that 4-aminobenzoic acid and glutamic acid in aqueous solution have obvious and unique characteristic absorption peaks in the frequency band of 0.1-2.0 THz when the effect of water on THz wave absorption is removed.The acquisition of characteristic absorption spectrum of amino acid aqueous solution in THz frequency band lays a foundation for the detection of active biological macromolecules or tissues.

关 键 词：太赫兹光谱测量 平行平板波导 4-氨基苯甲酸 谷氨酸 

分 类 号：TQ226.36[化学工程—有机化工]