儿童总摄氟量基准剂量的研究  

Benchmark dose of the children's total fluoride intake

作　　者：熊传龙[1] 张继国 王华东[3] 刘洋[4] 汪旸[5] 马景[6] 汪春雷[7] 李晓茜[8] 李洪兴[1] 张荣[1] Xiong Chuanlong;Zhang Jiguo;Wang Huadong;Liu Yang;Wang Yang;Ma Jing;Wang Chunlei;Li Xiaoqian;Li Hongxing;Zhang Rong(Division of Rural Drinking Water Monitor,National Center for Rural Supply Technical Guidance of Chinese Center for Disease Control and Prevention,Beijing 102200,China;Division of Public Nutrition and Policy Standard,Institute of Nutrition&Health of Chinese Center for Disease Control and Prevention,Beijing 100050,China;Institute of Endemic Disease,Anhui Center for Disease Prevention and Control,Hefei 230601,China;Institute of Endemic Disease,Henan Center for Disease Prevention and Control,Zhengzhou 450016,China;Jiangsu Center for Disease Prevention and Control,Nanjing 210009,China;Institute of Endemic Disease,Hebei Center for Disease Prevention and Control,Shijiazhuang 050021,China;Division of Fluorosis and Kaschin-Beck Diseases,Shandong Institute for Endemic Disease Prevention and Control,Jinan 250014,China;Division of Fluorosis and Arsenic Diseases,Shaanxi Institute for Endemic Disease Prevention and Control,Xi'an 710003,China)

机构地区：[1]中国疾病预防控制中心农村改水技术指导中心农村饮水监测室,北京102200 [2]中国疾病预防控制中心营养与健康所公共营养与政策标准室,北京100050 [3]安徽省疾病预防控制中心地病科,合肥230601 [4]河南省疾病预防控制中心地病所,郑州450016 [5]江苏省疾病预防控制中心,南京210009 [6]河北省疾病预防控制中心地病科,石家庄050021 [7]山东省地方病防治研究所氟与大骨节病室,济南250014 [8]陕西省地方病防治研究所氟砷室,西安710003

出　　处：《中华地方病学杂志》2021年第5期350-354,共5页Chinese Journal of Endemiology

基　　金：国家卫生和计划生育委员会卫生行业专项(201302004)。

摘　　要：目的探讨儿童总摄氟量来源以及儿童总摄氟量与氟斑牙患病之间的关系,计算总摄氟量的基准剂量(BMD)及其95%可信限的下限(BMDL),为《人群总摄氟量》(WS/T 87-2016)修订提供依据。方法2014年4月,在江苏、山东、河北、安徽、河南和陕西6个省份抽取改水年限在5年及以上、饮水氟含量在0.3~3.0 mg/L的村。采集调查村集中式供水的末梢水水样,离子选择电极法检测水氟含量;抽取调查村8~12岁儿童,Dean法检查氟斑牙患病情况;双份饭法(连续3日测量儿童每餐膳食和饮水量)调查儿童膳食及饮水量,《食品中氟的测定方法》测定儿童膳食氟含量;计算儿童饮水氟摄入量、膳食氟摄入量及总摄氟量;根据儿童总摄氟量与氟斑牙检出率之间的剂量-反应关系,计算儿童总摄氟量的BMD及BMDL,并基于BMDL计算参考剂量(RfD)。结果共调查29个村,水氟平均含量为1.26 mg/L,范围为0.41~2.85 mg/L;共检查3043名8~12岁儿童,氟斑牙检出率为30.2%(919/3043),儿童氟斑牙检出率最低的村为2.0%(2/100),最高的村为71.4%(30/42)。共调查769名8~12岁儿童膳食及饮水量,儿童每日饮水氟摄入量、膳食氟摄入量、总摄氟量分别为(0.83±0.66)、(1.13±0.61)、(1.96±0.89)mg/d。8~12岁儿童每日总摄氟量的BMD为2.43 mg,BMDL为2.21 mg,RfD为2.21 mg。结论本次研究所得的8~12岁儿童每日总摄氟量的BMD与《人群总摄氟量》(WS/T 87-2016)国家卫生标准的允许限值(2.4 mg)相近。Objective By exploring the source of children's total fluoride intake and the relationship between children's total fluoride intake and dental fluorosis prevalence,to calculate the benchmark dose(BMD)of children's total fluoride intake and its 95%confidence lower limit(BMDL),and to provide the basis for revision of"Total Fluoride Intake for Inhabitants"(WS/T 87-2016).Methods The villages that had water improvement for 5 years and more in 6 provinces of Jiangsu,Shandong,Hebei,Anhui,Henan and Shaanxi were selected as survey sites in April 2014.The water fluoride content of these villages was 0.3-3.0 mg/L,tap water samples from the centralized water supply were collected,and fluoride content was detected by ion selective electrode method.Children aged 8 to 12 years were selected,children's dental fluorosis was checked by Dean's method.Children's dietary and drinking water volume were surveyed by duplicate portion study(measurement for 3 d),and dietary fluoride content was detected according to the"Method for Determination of Fluorine in Foods".The mean and standard deviation of drinking water fluoride intake,dietary fluoride intake,and total fluoride intake were measured.According to the dose-response relationship between children's total fluoride intake and the detection rate of dental fluorosis,BMD and BMDL were calculated,and the reference dose(RfD)was calculated based on BMDL.Results The mean of water fluoride of all 29 villages was 1.26 mg/L(from 0.41 to 2.85 mg/L).Totally 3043 children aged 8 to 12 years were checked,and the detection rate of dental fluorosis was 30.2%(919/3034).The lowest detection rate of dental fluorosis was 2.0%(2/100)and the highest was 71.4%(30/42)in the 29 villages.The children's dietary and drinking water volume of 769 person-time aged 8 to 12 years were surveyed,the children's daily drinking water fluoride intake,dietary fluoride intake,and total fluoride intake were(0.83±0.66),(1.13±0.61)and(1.96±0.89)mg/d,respectively.The BMD of children's daily total fluoride intake was 2.43 mg,

关 键 词：饮水 氟 牙 基准剂量 总摄氟量 

分 类 号：R153.2[医药卫生—营养与食品卫生学]