In-Cell Nanoelectronics:Opening the Door to Intracellular Electrophysiology  

作　　者：Dongxin Xu Jingshan Mo Xi Xie Ning Hu 

机构地区：[1]State Key Laboratory of Optoelectronic Materials and Technologies,Guangdong Province Key Laboratory of Display Material and Technology,School of Electronics and Information Technology,Sun Yat-Sen University,Guangzhou 510006,People’s Republic of China [2]The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,People’s Republic of China [3]State Key Laboratory of Transducer Technology,Chinese Academy of Sciences,Shanghai 200050,People’s Republic of China

出　　处：《Nano-Micro Letters》2021年第8期191-217,共27页纳微快报（英文版）

基　　金：The work is supported in part by the National Natural Science Foundation of China(Grant Nos.82061148011,61771498);Guangdong Basic and Applied Basic Research Foundation(Grant No.2020A1515010665);Department of Science and Technology of Guangdong Province Project(Grant No.2020B1212060030);Foundation of Sun Yat-sen University(Grant Nos.76120-18821104,20lgpy47,20lgzd14);Open Project of Chinese Academy of Sciences(Grant No.SKT2006).

摘　　要：Establishing a reliable electrophysiological recording platform is crucial for cardiology and neuroscience research.Noninvasive and label-free planar multitransistors and multielectrode arrays are conducive to perform the large-scale cellular electrical activity recordings,but the signal attenua-tion limits these extracellular devices to record subthreshold activities.In recent decade,in-cell nanoelectronics have been rapidly developed to open the door to intracellular electrophysi-ology.With the unique three-dimensional nanotopography and advanced penetration strategies,high-throughput and high-fidelity action potential like signal recordings is expected to be realized.This review summarizes in-cell nanoelectronics from versatile nano-biointerfaces,penetration strategies,active/pas-sive nanodevices,systematically analyses the applications in electrogenic cells and especially evaluates the influence of nanodevices on the high-quality intracellular electrophysiological signals.Further,the opportunities,challenges and broad prospects of in-cell nanoelectronics are prospected,expecting to promote the development of in-cell electrophysiological platforms to meet the demand of theoretical investigation and clinical application.

关 键 词：In-cell nanoelectronics Nano-biointerfaces Intracellular electrophysiology Electrogenic cells 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]