重复经颅磁刺激治疗在青少年强迫症患者中的应用效果  

Application Effect of Repetitive Transcranial Magnetic Stimulation in Adolescent Patients with Obsessive-compulsive Disorder

作　　者：林冬梅[1] 黄丽宏[1] 曹阳 朱丛俏 LIN Dongmei;HUANG Lihong;CAO Yang;ZHU Congqiao(Psychological Sleep Adjustment Center,Jilin Neuropsychiatric Hospital,Siping,Jilin Province,136000 China)

机构地区：[1]吉林省神经精神病医院心理睡眠调适中心,吉林四平136000

出　　处：《中外医疗》2021年第11期4-7,共4页China & Foreign Medical Treatment

摘　　要：目的研究重复经颅磁刺激(rTMS)治疗在青少年强迫症患者中的应用效果。方法方便选取该院在2020年1—6月期间收治的92例青少年强迫症患者作为研究对象,使用单双数分组法将其分为对照组(46例)与研究组(46例),对照组给予盐酸舍曲林联合rTMS假刺激治疗,研究组应用盐酸舍曲林联合rTMS治疗。比较研究组与对照组治疗4、10周后的焦虑症、强迫症改善情况及治疗总有效率、安全性。结果治疗4、10周后,研究组汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评分、耶鲁布朗强迫症量表(Yale-Brown Obsessive Compulsive Scale,Y-BOCS)评分均低于对照组,差异均有统计学意义(t=-6.414、-15.131、-2.943、-4.174,P<0.05);研究组治疗总有效率(95.65%)明显高于对照组(65.22%),差异有统计学意义(χ^(2)=13.538,P<0.05);比较两组的不良反应发生率,差异无统计学意义(χ^(2)=0.080,P>0.05)。结论盐酸舍曲林与rTMS联合治疗青少年强迫症可有效控制患者的强迫症状,缓解焦虑,且不会增加不良反应,具有临床应用价值。Objective To study the effect of repeated transcranial magnetic stimulation(rTMS)therapy in adolescent patients with obsessive-compulsive disorder.Methods It is convenient to select 92 adolescent obsessive-compulsive disorder patients admitted in the hospital from January to June 2020 were selected as the research objects,and they were divided into the control group(46 cases)and the study goup(46 cases)using the odd and even number grouping method,the control group was treated with sertraline hydrochloride combined with rTMS sham stimulation,and the study group was treated with sertraline hydrochloride combined with rTMS.The improvement of anxiety and obsessive-compulsive disorder and the total effective rate and safety of the study group and the control group after 4 weeks and 10 weeks of treatment were compared.Results After 4 weeks and 10 weeks of treatment,the Hamilton Anxiety Scale(HAMA)scores and Yale-Brown Obsessive Compulsive Scale(Y-BOCS)scores of the study group were lower than those of the control group.The differences were statistically significant(t=-6.414,-15.131,-2.943,-4.174,P<0.05);the total effective rate of treatment in the study groupwas(95.65%)significantly higher than that of the control group(65.22%),and the difference was statistically significant(χ^(2)=13.538,P<0.05);compared the incidence of adverse reactions between the two groups,the difference was not statistically significant(χ^(2)=0.080,P>0.05).Conclusion The combination of sertraline hydrochloride and rTMS in the treatment of obsessive-compulsive disorder in adolescents can effectively control the obsessive-compulsive symptoms of patients,relieve anxiety,and will not increase adverse reactions,and has clinical application value.

关 键 词：盐酸舍曲林 RTMS 青少年强迫症 HAMA Y-BOCS 

分 类 号：R5[医药卫生—内科学]