Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion  

作　　者：Pooyan Makvandi Melissa Kirkby Aaron RJHutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly 

机构地区：[1]Istituto Italiano Di Tecnologia,Centre for Materials Interface,Viale Rinaldo Piaggio 34,56025 Pontedera,Pisa,Italy [2]School of Pharmacy,Queen’s University Belfast,97 Lisburn Road,Belfast BT97BL,UK [3]The BioRobotics Institute,Scuola Superiore Sant’Anna,Viale Rinaldo Piaggio 34,56025 Pontedera,Pisa,Italy [4]Paediatric Dentistry and Orthodontics,Faculty of Dentistry,The University of Hong Kong,Prince Philip Dental Hospital,Hong Kong SAR,China [5]Department of Chemical,Materials and Industrial Production Engineering,University of Naples FedericoⅡ,80125 Naples,Italy [6]Center for Advanced Biomaterials for Health Care(iit@CRIB),Italian Institute of Technology,80125 Naples,Italy

出　　处：《Nano-Micro Letters》2021年第6期190-230,共41页纳微快报（英文版）

基　　金：the European Horizon 2020 Research and Innovation Programme under Grant Agreement No.899349(5D NanoPrinting).

摘　　要：Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the skin.To serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during penetration.This ensures that the cargo is released at the predetermined place and time.Therefore,the ability of MN patches to sufficiently pierce the skin is a crucial requirement.In the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared.This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice.Factors that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research.

关 键 词：Insertion responsive Implantable microneedles Skin indentation Transdermal microneedles Pain management 

分 类 号：R943[医药卫生—药剂学] TQ460.1[医药卫生—药学]