Sniffing Bacteria with a Carbon-Dot Artificial Nose  

作　　者：Nitzan Shauloff Ahiud Morag Karin Yaniv Seema Singh Ravit Malishev Ofra Paz-Tal Lior Rokach Raz Jelinek 

机构地区：[1]Department of Chemistry,Ben Gurion University of the Negev,84105 Beer Sheva,Israel [2]Department of Biotechnology Engineering,Ben Gurion University of the Negev,84105 Beer Sheva,Israel [3]Chemistry Department,Nuclear Research Center,Negev,P.O.Box 9001,84190 Beer Sheva,Israel [4]Department of Software and Information System Engineering,Ben-Gurion University of the Negev,Beer Sheva,Israel [5]Ilse Katz Institute for Nanotechnology,Ben Gurion University of the Negev,84105 Beer Sheva,Israel

出　　处：《Nano-Micro Letters》2021年第7期138-152,共15页纳微快报（英文版）

基　　金：We are grateful to Dr.Natalya Froumin(XPS),Dr.Yanna Milionshi(TGA),Dr.Jurgen Jopp(AFM),Dr.Igor Mokmanov for assistance with GC-MS experiments and Mrs.Galia Strinkovski for mentoring.

摘　　要：Continuous,real-time monitoring and identification of bacteria through detection of microbially emitted volatile molecules are highly sought albeit elusive goals.We introduce an artificial nose for sensing and distinguishing vapor molecules,based upon recording the capacitance of interdigitated electrodes(IDEs)coated with carbon dots(C-dots)exhibiting different polarities.Exposure of the C-dot-IDEs to volatile molecules induced rapid capacitance changes that were intimately dependent upon the polarities of both gas molecules and the electrode-deposited C-dots.We deciphered the mechanism of capacitance transformations,specifically substitution of electrode-adsorbed water by gas molecules,with concomitant changes in capacitance related to both the polarity and dielectric constants of the vapor molecules tested.The C-dot-IDE gas sensor exhibited excellent selectivity,aided by application of machine learning algorithms.The capacitive C-dot-IDE sensor was employed to continuously monitor microbial proliferation,discriminating among bacteria through detection of distinctive“volatile compound fingerprint”for each bacterial species.The C-dot-IDE platform is robust,reusable,readily assembled from inexpensive building blocks and constitutes a versatile and powerful vehicle for gas sensing in general,bacterial monitoring in particular.

关 键 词：Carbon dots Bacterial detection Bacterially emitted volatile molecules Capacitive gas sensors Gas polarity 

分 类 号：O62[理学—有机化学]